Skip to main content
Log in

The pharmacodynamic and pharmacokinetic interaction of flecainide acetate with propranolol: Effects on cardiac function and drug clearance

  • Short Communications
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Hoback J, Hodges M, Francis GS, Sharma B, Asinger RW (1978) Flecainide (R-818), a new antiarrhythmic agent: Effects on ventricular premature beats. Circulation 58 (Suppl II): 246 (Abstract 959)

    Google Scholar 

  2. Somani P (1980) Antiarrhythmic effects of flecainide. Clin Pharmacol Ther 27: 464–470

    Article  PubMed  CAS  Google Scholar 

  3. Anderson JL, Stewart JR, Perry BA, Van Hamersveld DD, Johnson TA, Conard GJ, Chang SF, Kvam DC, Pitt B (1981) Oral flecainide acetate for the treatment of ventricular arrhythmias. N Engl J Med 305: 473–477

    Article  PubMed  CAS  Google Scholar 

  4. Duff HF, Roden DM, Maffucci RJ, Vesper BS, Conard GJ, Higgins SG, Oates JA, Smith RF, Woosley RL (1981) Suppression of resistant ventricular arrhythmias by twice daily dosing with flecainide. Am J Cardiol 48: 1133–1140

    Article  PubMed  CAS  Google Scholar 

  5. Hodges M, Haugland JM, Granrud G, Conard GJ, Asinger RW, Mikell FL, Krejci J (1982) Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agent. Circulation 65: 879–885

    PubMed  CAS  Google Scholar 

  6. Krebs R (1983) Adverse reactions with calcium antagonists. Hypertension 5 (Suppl II): II125-II129

    PubMed  CAS  Google Scholar 

  7. Holtzman JL, Berry DA, Kvam DC, Mottonen L, Borrell G (1984) Application of second order polynomial equations to the study of pharmacodynamic interactions: the effect of flecainide acetate and propranolol on cardiac output and vascular resistance. J Pharmacol Exp Therap 231: 286–290

    CAS  Google Scholar 

  8. Weissler AM, Davis WS, Schoenfeld CD (1964) Bedside techniques for the evaluation of ventricular function in man. Am J Cardiol 23: 577–583

    Article  Google Scholar 

  9. Kelman AW, Sumner DJ, Whiting B (1981) The prediction of individual systolic time interval heart rate regression equations. Br J Clin Pharmacol 12: 21–30

    PubMed  CAS  Google Scholar 

  10. Johnson JD, Carlson GL, Fox JM, Miller AM, Chang SF, Conard GJ (1984) Quantitation of flecainide acetate, a new antiarrhythmic, in biological fluids by gas chromatography with electron capture detection. J Pharm Sci 73: 1469–1471

    PubMed  CAS  Google Scholar 

  11. Roden DM, Woosley RL (1986) Drug therapy: Flecainide. N Engl J Med 315: 36–41

    Article  PubMed  CAS  Google Scholar 

  12. Lewis RP, Rittgers SE, Forester WF, Boudoulas H (1977) A critical review of the systolic time intervals. Circulation 56: 146–158

    PubMed  CAS  Google Scholar 

  13. Legrand W, VanDormael M, Collignon P, Kulbertus HE (1983) Hemodynamic effects of a new antiarrhythmic agent, flecainide (R-818), in coronary heart disease. Am J Cardiol 51: 422–426

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Holtzman, J.L., Kvam, D.C., Berry, D.A. et al. The pharmacodynamic and pharmacokinetic interaction of flecainide acetate with propranolol: Effects on cardiac function and drug clearance. Eur J Clin Pharmacol 33, 97–99 (1987). https://doi.org/10.1007/BF00610389

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00610389

Key words

Navigation