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Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men

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Summary

The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose.

Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7–57.9 h in these elderly men.

The elimination half-life was twice as long when compared to a study previously performed in young volunteers.

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Authors and Affiliations

  1. Poisons Unit, New Cross Hospital, London, UK

    J. M. Streete & D. J. Berry

  2. Department of Life Sciences, University of London Goldsmiths' College, New Cross, London, UK

    J. E. Newberry

  3. George Stamp Unit, Orpington Hospital Orpington, Kent, UK

    P. Crome

Authors
  1. J. M. Streete
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  2. D. J. Berry
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  3. J. E. Newberry
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  4. P. Crome
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Streete, J.M., Berry, D.J., Newberry, J.E. et al. Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men. Eur J Clin Pharmacol 33, 431–434 (1987). https://doi.org/10.1007/BF00637644

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  • DOI: https://doi.org/10.1007/BF00637644

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