Summary
Felodipine (0.075 mg/kg p.o.), a calcium antagonist, was given to 9 male volunteers, with and without indomethacin pretreatment.
Diuresis and natriuresis occurred after felodipine without significant change in effective renal plasma flow or glomerular filtration rate.
There was no significant change in urinary 6 keto PGF 1 α or urinary kallikrein excretion and indomethacin did not inhibit the natriuretic or diuretic response to felodipine.
The felodipine induced diuresis and natriuresis appears most likely to be mediated by an action of the drug on renal tubules.
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References
Loutzenheiser R, Epstein M (1985) Effects of calcium antagonists on renal haemodynamics. Am J Physiol 249: F619-F629
Klutsch K, Schmidt P, Grosswendt J (1972) Der Einfluß von Bay a 1040 auf die Nierenfunktion des Hypertonikers. Arzneimittelforsch/Drug Res 22: 377–380
Krusell LR, Christiansen CK, Lederballe Pederson O (1987) Acute natriuretic effect of nifedipine in hypertensive patients and normotensive controls — a proximal tubular effect? Eur J Clin Pharmacol 32: 121–126
Van Schaik Bam, Van Nistelrooy AEJ, Geyskes GG (1984) Antihypertensive and renal effects of nicardipine. Br J Clin Pharmacol 18: 57–63
Wallia R, Greenberg A, Puschett JB (1985) Renal haemodynamic and tubular transport effects of nitrendipine. J Lab Clin Med 105: 498–503
Wathen CG, MacLeod D, Tucker L, Muir AL (1985) Felodipine as an alternative to minoxidil in severe refractory hypertension. Drugs 27 [Suppl 2]: 157–158
Schmitz A (1987) Acute renal effects of oral felodipine in normal man. Eur J Clin Pharmacol 32: 17–22
Di Bona GF, Sawin LL (1984) Renal tubular site of action of felodipine. J Pharmacol Exp Ther 28 (2): 420–424
Nasjletti A, Malik KU (1981) Renal kinin-prostaglandin relationship: Implications for renal function. Kidney Int 19: 860–868
Mills IH (1982) The renal kallikrein-kinin system and sodium excretion. Q J Exp Physiol 67: 393–399
Harvey RB, Brothers AJ (1962) Renal excretion of para-aminohippurate and creatinine measured by continuous in vivo sampling of arterial and renal vein blood. Ann N Y Acad Sci 102: 46–54
Dawborn JK (1965) Applications of Heyronsky's inulin method to automatic analysis. Clin Chim Acta 12: 63–66
Watson ML, Lambie AT, Thom A, Ungar A (1982) Role of prostaglandins in mediating excretion by the kidney of an intravenous infusion of sodium chloride in normal human subjects. Clin Sci 62: 27–33
Amundsen E, Putter J, Friberger P, Knoos M, Larsbraten M, Claeson G (1979) Methods for the determination of glandular kallikrein by means of a chromogenic tripeptide substrate. Adv Exp Med Biol 120 A: 83–95
Ek B, Sjolander R, Di Bona GF, Hallback-Nordlander M, Ljung B (1985) Effect of felodipine on renal haemodynamics and excretion in the dog. Proc Soc Exp Biol Med 179: 201–205
Jones RL, Watson ML, Ungar A (1981) A comparison of the effect of prostaglandins E2 and I2 on renal function and renin release in salt-loaded and salt-depleted anaesthetized dogs. Q J Exp Physiol 66: 1–15
Dunn MJ (1983) Renal prostaglandins. In: Dunn MJ (ed) Renal endocrinology. Williams & Wilkins, Baltimore, pp 1–74
Diamond JR, Cheung JY, Fang LST (1984) Nifedipine induced renal dysfunction. Am J Med 77: 905–909
Berl T (1981) Cellular calcium uptake in the action of prostaglandins on renal water excretion. Kidney Int 19: 15–23
Barajas L, Powers K, Carretero O, Guillermo Schilli A, Inagami T (1986) Immunocytochemical localization of renin and kallikrein in the rat renal cortex. Kidney Int 29: 965–970
Levinsky NG (1979) The renal kallikrein-kinin system. Circ Res 44: 441–451
Watson ML, Cumming AD, Lambie AT, Oates JA (1985) Urinary kallikrein and systemic prostacyclin synthesis during sodium infusion in normal man. Clin Sci 68: 537–543
Mackay IG, Nath K, Cumming AD, Muir AL, Watson ML (1985) Haemodynamic and endocrine responses of the kidney to frusemide in essential hypertension. Clin Sci 68: 159–164
Kramer HJ, Dusing R, Glenzer K, Kipnowski J, Klingmuller D, Meyer-Lehnert H (1984) Effects of aprotinin on renal function. Contrib Nephrol 42: 233–241
Seeber AM, Vila SB, Catanzaro OL (1982) The mechanism of urinary kallikrein excretion in the rat. Clin Sci 63: 217–218
Agner E, Rehling M, Trap-Jensen J (1985) Haemodynamic effects of single dose felodipine in normal men. Drugs 29 [Suppl 2]: 36–40
Dietz JR, Davis JO, Freeman RH, Villareal D, Ecktenkamp SF (1983) Effects of intrarenal infusion of calcium entry blockers in anaesthetized dogs. Hypertension 5: 482–488
Valdes G, Soto ME, Croxatto HR, Bellolio T, Corbalan R, Casanegra P (1982) Effects of nifedipine during low normal and high intake of sodium in patients with essential hypertension. Clin Sci 63: 447s-450s
Marone C, Luisoli S, Bonio F, Beretta-Piccoli C, Bianchetti MG, Weidmann P (1985) Body sodium-blood volume state, aldosterone and cardiovascular responsiveness after calcium entry blockade with nifedipine. Kidney Int 28: 658–665
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Jenkins, D.A.S., Craig, K., Cumming, A.D. et al. The acute renal haemodynamic and endocrine response to felodipine in normal man. Eur J Clin Pharmacol 33, 581–585 (1988). https://doi.org/10.1007/BF00542491
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DOI: https://doi.org/10.1007/BF00542491