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Beta-blockade antagonism of tyramine-induced rise in blood pressure

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The effect β-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1–6 mg, alternating with saline, in a randomized, single blind fashion.

Prior to treatment tyramine caused a temporary, dose-dependent increase in systolic and diastolic blood pressure, whilst the heart rate remained unaffected. Both propranolol and indenolol reduced the pressor response to tyramine, as shown by a significant increase in ED15, i.e. the dose of tyramine required to increase systolic blood pressure by 15%.

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Colombo, F., Sega, R., Mailland, F. et al. Beta-blockade antagonism of tyramine-induced rise in blood pressure. Eur J Clin Pharmacol 34, 263–266 (1988). https://doi.org/10.1007/BF00540953

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  • DOI: https://doi.org/10.1007/BF00540953

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