Summary
Clofibrate inhibits the synthesis of adrenal steroids when administered in vitro. In the present study the effect in vivo of clofibrate on adrenal steroid secretion has been investigated. Basal levels of plasma progesterone, corticosterone, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone, and their response to ACTH 1 mg im, were not reduced by chronic administration of clofibrate 2 g per day p.o. for 8 to 34 days to 6 hyperlipidaemic men.
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References
Thorp JM, Waring WS (1962) Modification of metabolism and distribution of lipids by ethyl chlorophenoxyisobutyrate. Nature 194: 948–949
Olsson AG, Orö L, Rössner S (1975) Dose-response effect of single and combined clofibrate (Atromidin) and niceritrol (Perycit) treatment on serum lipids and lipoproteins in type II hyperlipoproteinaemia. Atherosclerosis 22: 91–101
Touitou Y, Legrand JC, Desgrez P (1971) Mise en évidence de l'effet inhibiteur du clofibrate (parachlorophénoxyisobutyrate d'éthyle) sur la biosynthèse de la 18-hydroxycorticostérone et de l'aldostérone par incubation d'une surrénale humaine et de surrénales de moutons in vitro. C R Acad Sci [D] (Paris) 273: 2587–2590
Huffman DH, Azarnoff DL (1967) The effect of hypocholesterolemic drugs on adrenal corticosteroid secretion. Steroids 9: 41–51
Saffran J, Saffran M, Salhanick HA (1970) Clofibrate inhibits lipid synthesis and ACTH-stimulated steroidogenesis by rat adrenal tissue. Endocrinology 86: 652–655
Mc Intosh EN, Uzgiris VI, Salhanick HA (1970) Clofibrate inhibition of 11β-hydroxylation in bovine adrenal cortex mitochondria. Endocrinology 86: 656–667
Gennes JL de, Dairou F, Truffert J (1981) Double screening test at 8th and 12th hour of overnight fasting for a better classification of idiopathic hyperlipidemias. Large scale study of 505 tests. Diabete Metab 7: 161–167
Téa NT, Castanier M, Roger M, Scholler R (1975) Simultaneous radioimmunoassay of plasma progesterone and 17-hydroxyprogesterone. Normal values in children, in men and in women throughout the menstrual cycle and in early pregnancy. J Steroid Biochem 6: 1509–1516
Gennes JL de, Jambart S, Turpin G, Elkik F, Roger M (1982) 17α-hydroxylase deficiency syndrome associated with bilateral streak gonads and impaired development of Müllerian ducts derivatives. Report of a case. Acta Endocrinol (Copenh) 100: 68–76
Roger M, Nahoul K, Toublanc JE, Castanier M, Canlorbe P, Job JC (1979) Les androgènes plasmatiques chez le garçon de la naissance à l'adolescence. Ann Pediatr (Paris) 26: 239–245
Greenhouse AH (1968) Attempted suicide with clofibrate. J Am Med Assoc 204: 402–403
Houin G, Thébault JJ, D'Athis P, Tillement JP, Beaumont JL (1975) A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man. Eur J Clin Pharmacol 8: 433–437
Cailleux A, Allain P, Tadei A (1976) Etude pharmacocinétique des hypolipémiants dérivés de l'acide clofibrique chez l'homme après administration unique et répétéc. Therapie 31: 637–645
Baldwin JR, Witiak DT, Feller DR (1980) Disposition of clofibrate in the rat. Acute and chronic administration. Biochem Pharmacol 29: 3143–3154
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Heshmati, H.M., Turpin, G., Touitou, Y. et al. Lack of effect in vivo of clofibrate on adrenal steroid secretion. Eur J Clin Pharmacol 36, 87–89 (1989). https://doi.org/10.1007/BF00561031
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DOI: https://doi.org/10.1007/BF00561031