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Comparison of the gastroduodenal tolerance of tenoxicam and diclofenac Na

A double-blind, endoscopically controlled study in healthy volunteers

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Summary

The gastroduodenal tolerance of Tenoxicam and Diclofenac Na has been evaluated in a double-blind, parallel group study in 36 healthy male volunteers. The doses used were 20 mg Tenoxicam and 100 mg Diclofenac Na daily in a retard formulation for 14 days.

Gastric tolerance was assessed by endoscopy, which was performed at base-line, after the 14 day dosing period and after a 14 day follow-up period without treatment. The mucosal lesions were scored using modified Lanza criteria.

Tenoxicam was significantly better tolerated at the end of the 14 day dosing period (mean gastric score: Tenoxicam 1.3; Diclofenac Na 2.2). The two treatment groups had comparable scores at the base-line and post study assessments.

Tenoxicam and Diclofenac Na were generally well tolerated. Only two volunteers reported intermittant lack of appetite, heartburn and a feeling of pressure in the stomach.

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Authors and Affiliations

  1. Gastroenterologische Abteilung, Medizinische Universitätsklinik Heidelberg, Heidelberg, Federal Republik of Germany

    P. Müller, H. G. Dammann, U. Leucht & B. Simon

  2. Krankenhaus Schwetzingen, Schwetzingen, Federal Republik of Germany

    P. Müller, H. G. Dammann, U. Leucht & B. Simon

Authors
  1. P. Müller
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  2. H. G. Dammann
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  3. U. Leucht
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  4. B. Simon
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Müller, P., Dammann, H.G., Leucht, U. et al. Comparison of the gastroduodenal tolerance of tenoxicam and diclofenac Na. Eur J Clin Pharmacol 36, 419–421 (1989). https://doi.org/10.1007/BF00558307

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  • DOI: https://doi.org/10.1007/BF00558307

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