Summary
A pharmacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets.
Oral DIEP 2×50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to oral diclofenac sodium 2×50 mg. A relevant plasma concentration of diclofenac was detected just 15 min after DIEP, while diclofenac sodium produced a measurable plasma concentration only 0.5–1 h after the treatment. Cmax and t1/2 after DIEP and diclofenac sodium were comparable. Comparison of the two AUC values showed that DIEP was bioequivalent to diclofenac sodium (Q=100%).
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Maggi, C.A., Lualdi, P. & Mautone, G. Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man. Eur J Clin Pharmacol 38, 207–208 (1990). https://doi.org/10.1007/BF00265987
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DOI: https://doi.org/10.1007/BF00265987