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Effect of amiodarone on 3H-ouabain binding sites in human skeletal muscle

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Summary

Na,K-ATPase, or the Na,K-pump, is essential for the excitability and contractility of muscle tissue. Hypothyroidism in associated with a marked decrease in the Na,K-pump concentration in skeletal muscle and myocardium.

In 7 patients on long-term amiodarone treatment there was a 36% reduction in the concentration of 3H-ouabain binding sites in skeletal muscle biopsies compared to 7 healthy subjects.

This decrease during long-term amiodarone treatment may represent an equivalent reduction in the concentration of the functional Na,K-pump and it may be important in the adverse effect of amiodarone on muscle.

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References

  1. Latham KR, Sellitti DF, Goldstein RE (1987) Interaction of amiodarone and desethylamiodarone with solubilized nuclear thyroid hormone receptors. J Am Coll Cardiol 9: 872–876

    Google Scholar 

  2. Kjeldsen K, Nørgaard A, Gøtzsche CO, Thomassen A, Clausen T (1984) Effect of thyroid function on the number of Na-K-pumps in human skeletal muscle. Lancet II: 8–10

    Google Scholar 

  3. Nørgaard A, Kjeldsen K, Hansen O (1985) K-dependent 3-O-methylfluorescein phosphatase activity in crude homogenate of rodent heart ventricle: effect of K-depletion and changes in thyroid function. Eur J Pharmacol 113: 373–382

    Google Scholar 

  4. Brien JF, Jimmo S, Armstrong PW (1983) Rapid high-performance liquid chromatographic analysis of amiodarone and N-desethyl-amiodarone in serum. Can J Physiol Pharmacol 61: 245–248

    Google Scholar 

  5. Chatelain P, Laruel R, Gillard M (1985) Effect of amiodarone on membrane fluidity and Na/Ka ATPase activity in rat-brain synaptic membranes. Biochem Biophys Res Commun 129: 148–154

    Google Scholar 

  6. Nørgaard A, Bagger JP, Bjerregaard P, Baandrup U, Kjeldsen K, Bloch Thomsen PE (1988) Relation of left ventricular function and Na,K-pump concentration in suspected idiopathic dilated cardiomyopathy. Am J Cardiol 61: 1312–1315

    Google Scholar 

  7. Kim D, Akera T, Brody TM (1981) Effects of quinidine on the cardiac glycoside sensitivity of guinea pig and rat heart. J Pharmacol Exp Ther 217: 559–565

    Google Scholar 

  8. Clausen T, Everts M (1989) Regulation of the Na,K-pump in skeletal muscle. Kidney Int 35: 1–13

    Google Scholar 

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Nørgaard, A., Jensen, J.H. & Andreasen, F. Effect of amiodarone on 3H-ouabain binding sites in human skeletal muscle. Eur J Clin Pharmacol 38, 397–399 (1990). https://doi.org/10.1007/BF00315584

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  • DOI: https://doi.org/10.1007/BF00315584

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