Summary
Na,K-ATPase, or the Na,K-pump, is essential for the excitability and contractility of muscle tissue. Hypothyroidism in associated with a marked decrease in the Na,K-pump concentration in skeletal muscle and myocardium.
In 7 patients on long-term amiodarone treatment there was a 36% reduction in the concentration of 3H-ouabain binding sites in skeletal muscle biopsies compared to 7 healthy subjects.
This decrease during long-term amiodarone treatment may represent an equivalent reduction in the concentration of the functional Na,K-pump and it may be important in the adverse effect of amiodarone on muscle.
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Nørgaard, A., Jensen, J.H. & Andreasen, F. Effect of amiodarone on 3H-ouabain binding sites in human skeletal muscle. Eur J Clin Pharmacol 38, 397–399 (1990). https://doi.org/10.1007/BF00315584
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DOI: https://doi.org/10.1007/BF00315584