Summary
Reproducibility of Doppler blood velocity waveform measurements in external and internal carotid, middle cerebral, and brachial arteries and ascending aorta was determined in 8 normal male volunteers twice daily on three occasions each separated by two or more weeks.
Measurements were made in supine and standing positions at rest and after taking glyceryl trinitrate and in the supine position after performing a standardized exercise test.
The Doppler blood flow waveform indices showed a between days coefficient of variation of less than 15% both for baseline measurements and during haemodynamic change induced by exercise or glyceryl trinitrate.
We conclude that Doppler blood velocity waveform measurement in different vascular beds is reproducible at baseline and when the cardiovascular system is interrupted pharmacologically or physiologically.
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Beasley MG, Blau JN, Gosling RG (1979) Changes in internal carotid artery flow velocities with cerebral vasodilation and constriction. Stroke 10: 331–335
Blackshear WM, Phillips DJ, Chilios PM, Harley JD, Thiele BL, Strandness DE (1980) Carotid artery velocity patterns in normal and stenotic vessels. Stroke 11: 67–71
Bouthier J, Benetos A, Simon A, Levenson J, Safar M (1985) Pulsed Doppler evaluation of diameter blood velocity and blood flow of common carotid artery in sustained essential hypertension. J Cardiovascular Pharmacol 7 [Suppl 2]: S99-S104
Bouthier JD, Safar ME, Benetos A, Simon AC, Levenson JA, Hugues CM (1986) Haemodynamic effects of vasodilating drugs on the common carotid and brachial circulations of patients with essential hypertension. Br J Clin Pharmacol 21: 137–142
Burns PN (1987) The physical principles of Doppler and spectral analysis. J Clin Ultrasound 15: 567–590
Call GK, Abbott WM, Macdonald NR, Megerman J, Davis KR, Heros RC, Kistler P (1988) Correlation of continuous-wave Doppler spectral flow analysis with gross pathology in carotid stenosis. Stroke 19: 584–588
Campbell WB, Skidmore R, Baird RN (1984) Variability and Reproducibility of arterial Doppler waveforms. Ultrasound Med Biol 10: 601–606
Deshmukh VD, Harper AM (1973) The effect of serotonin on cerebral and extracranial blood flow with possible implications in migraine. Acta Neurol Scand 49: 649–658
Fischer M, Alexander K (1985) Reproducibility of carotid artery Doppler frequency measurements. Stroke 16: 973–976
Fraser CB, Light LH, Shinebourne EA, Buchtal A, Healy MJR, Beardshaw JA (1976) Transcutaneous aortovelography: reproducibility in adults and children. Eur J Cardiol 4: 181–189
Gardin JM, Dabestani A, Martin K, Allfie A, Russel D, Henry WL (1984) Reproducibility of Doppler aortic blood flow measurements: studies on intra observer, inter observer and day-to-day variability in normal subjects. Am J Cardiol 54: 1092–1098
Gerthoffer WT, Shafer PG, Taylor S (1987) Selectivity of phenytoin and dihydropyridine calcium channel blockers for relaxation of the basilar artery. J Cardiovasc Pharmac 10: 9–15
Gisvold SE, Brubakk AO (1982) Measurement of instantaneous blood flow velocity in the human aorta using pulsed Doppler ultrasound. Cardiovasc Res 16: 26–33
Gosling RG, King DH (1974) Continuous wave ultrasound and an alternative and complement to X-rays in vascular examinations. In: Reneman RS (ed) Cardiovascular applications of ultrasound. North-Holland, Amsterdam, pp 266–282
Halfdan I, Knut E, Yngvar M, Erik M (1987) Reproducibility of cardiac stroke volume estimated by Doppler echocardiography. Am J Cardiol 59: 975–978
Hastie SJ, Catherine AH, Martin JW, Rubin PC (1988) Daily variability of umbilical and lateral uterine wall artery blood velocity waveform measurements. Br J Obstet Gyn 95: 571–574
Hennerici M, Rautenberg W, Sitzer G, Schwartz A (1987) Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity — part 1 Examination technique and normal values. Surg Neurol 12: 439–448
MacDonald NJ, Butters L, O'Shaughnessy DJ, Riddell AJ, Rubin PC (1989) A comparison of the effects of human alpha calcitonin gene-related peptide and glyceryl trinitrate on regional blood velocity in man. Br J Clin Pharmacol 28: 257–261
McLennan FM, Haites NE, Mackenzie JD, Daniel MK, Rawles JM (1986) Reproducibility of linear cardiac output measurement by Doppler ultrasound alone. Br Heart J 55: 25–31
Mehta N, Boyle G, Bennet D, Gilmour S, Noble MIM, Mills CM, Pugh S (1988) Haemodynamic response to treadmill exercise in normal volunteers: An assessment of Doppler ultrasonic measurement of ascending aortic blood velocity and acceleration. Am Heart J 116: 1298–1307
Robson SC, Murray A, Peart I, Heads A, Hunter S (1988) Reproducibility of cardiac output measurement by cross-sectioned and Doppler echocardiography. Br Heart J 59: 680–684
Schneider PA, Rossman ME, Bernstein EF, Torem S, Ringelstein B, Otis SM (1988) Effects of internal carotid occlusion on intracranial haemodynamics Transcranial Doppler evaluation and clinical correlations. Stroke 19: 589–593
Safar ME, Bouthier JA, Levenson JA, Simon A (1983) Peripheral large arteries and the response to antihypertensive treatment. Hypertension 5: [Suppl 3]: 63–68
Uematsu S, Yang A, Preziosi TJ, Kouba R, Toung TJK (1983) Measurement of carotid blood flow in man and its clinical application. Stroke 14: 256–266
Wechsler LR, Ropper AH, Kistler JP (1986) Transcranial Doppler in cerebrovascular disease. Stroke 17: 905–912
Wetzner SM, Kiser LC, Bezreh JS (1984) Duplex ultrasound imaging: vascular applications. Radiology 150: 507–551
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Rimoy, G.H., Bhaskar, N.K. & Rubin, P.C. Reproducibility of Doppler blood flow velocity waveform measurements: study on variability within and between day and during haemodynamic intervention in normal subjects. Eur J Clin Pharmacol 41, 125–129 (1991). https://doi.org/10.1007/BF00265904
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DOI: https://doi.org/10.1007/BF00265904