Summary.
A newly developed calcium antagonist, nilvadipine, was administered to 7 hypertensive patients aged 75.6 y.
Nilvadipine 4 mg b.d. decreased the average 24-h blood pressure significantly from 169/89 mm Hg to 152/81 mm Hg after 7 to 14 days without any change in the pulse rate. The circadian patterns of blood pressure and pulse rate were not affected by nilvadipine.
Although the present study was a preliminary one done over a short period in a small number of patients, the results suggest that nilvadipine exerts an antihypertensive effect without altering the circadian pattern or the variability of blood pressure in elderly hypertensive patients.
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Tsuchihashi, T., Tsukashima, A., Matsumura, K. et al. Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine. Eur J Clin Pharmacol 41, 255–257 (1991). https://doi.org/10.1007/BF00315439
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DOI: https://doi.org/10.1007/BF00315439