Summary
Using a double blind, double dummy crossover design, single dose and steady state pharmacokinetics of oral controlled release (SCR) salbutamol 4 mg and 8 mg tablets b. d. has been studied in 8 Asian patients.
Plasma salbutamol was measured over 12 h. In 8 patients the single dose mean Cmax was 4.2 ng·ml−1 and 7.7 ng·ml−1 after 4 and 8 mg, respectively. In 5 patients the steady state mean Cmax, Cmin and tmax were 8.1 ng·ml−1 and 4.7 ng·ml−1 and 6 h for the 4 mg tablets and 14.1 ng·ml−1 and 7.1 ng·ml−1 and 4 h for the 8 mg tablets.
It is concluded that both doses of SCR show features of controlled release and that they produced a relatively constant plasma level of salbutamol in Asian patients.
References
Walker SR, Evans ME, Richards AJ, Patterson JW (1972) The clinical pharmacology of oral and inhaled salbutamol. Clin Pharmacol Ther 13: 681
Maconochie JG, Fowler P (1983) Plasma concentrations of salbutamol after an oral slow release preparation. Curr Med Res Opin 8: 634–639
Hutchings MJ, Paull JD, Morgan DJ (1983) Determination of salbutamol in plasma by high performance liquid chromatography with fluorescence detection. J Chromatogr 277: 423–426
Shenfield GM, Brogden RN, Ward A (1984) Pharmacology of Bronchodilators. In: Clark TJH, Chochrane GM (eds) Bronchodilator Therapy. Adis, Auckland, pp 17–46
Gregg I (1985) Asthma: Its management in general practice. Update, London, p 24
Sherwood Burge P (1984) Getting the best out of bronchodilator therapy. In Clark TJH, Cochrane GM (eds) Bronchodilator Therapy. Adis, Auckland, pp 58–75
Maesen FPV, Smeets JJ (1986) Comparison of a controlled release tablet of salbutamol given twice daily with standard tablet given four times daily in the management of chronic obstructive lung disease. Eur J Clin Pharmacol 31: 431–436
Lipworth BJ, Clark RA, Dhillon DP, Charter MK, Palmer JBD, McDevitt DG (1989) Single dose and steady state pharmacokinetics of 4 mg and 8 mg oral salbutamol controlled-release in patients with bronchial asthma. Eur J Clin Pharmacol 37: 49–52
Pickup ME, Harrison LP (1987) Determination of salbutamol in plasma by solid phase extraction and HPLC: Validation Report. BIOS Report 1490, Reg MEP/AM/MRK
Sykes RS, Reese ME, Meyer MC (1987) Pharmacokinetic properties of a new sustained release albuterol preparation, Volmax. J. Allergy Clin Immunol 79: 152 (Abstract)
Milroy R, Carter R, Carlyle DL, Boyd G (1987) Pharmacology of salbutamol with a new controlled release salbutamol preparation. Am Rev Respir Dis [Suppl] 135: A228
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tan, W.C., Lee, H.S. Pharmacokinetics of oral salbutamol controlled-release in Asian patients with asthma. Eur J Clin Pharmacol 41, 495–496 (1991). https://doi.org/10.1007/BF00626378
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00626378