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Time-dependent change in the effect of probucol in subjects with elevated cholesterol

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Summary

A time-dependent change in the cholesterol-lowering effect of probucol has been evaluated in 20 subjects with elevated cholesterol. Probucol 500 mg was given once daily at 07.00 h (day trial) or 19.00 h (night trial) for 3 months according to a crossover design. Fasting blood samples were obtained during the control period and at the end of each treatment period.

Serum concentrations of total and HDL-cholesterol were significantly decreased by both the treatments with probucol [total cholesterol (mmol · l−1): control 6.58; day trial 5.41; night trial 5.10; HDL-cholesterol (mmol · l−1): control 1.35; day trial 1.06; night trial 0.96]. These parameters were significantly lower in the night trial than in the day trial.

The data indicate that the cholesterol-lowering effect of probucol varies with its time of administration in subjects with elevated cholesterol.

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References

  1. Lemmer B (1989) Chronopharmacology Cellular Clocks Series vol. 3, Dekker, New York

    Google Scholar 

  2. Peters JR, Hunninghake DB (1985) Effect of time of administration of cholestyramine on plasma lipids and lipoproteins. Artery 13: 1–6

    CAS  PubMed  Google Scholar 

  3. Illingworth DR (1986) Comparative efficacy of once versus twice daily mevinolin in the therapy of familial hypercholesterolemia. Clin Pharmacol Ther 40: 338–343

    CAS  PubMed  Google Scholar 

  4. Buckley MMT, Goa KL, Price AH, Brogden RN (1989) Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia. Drugs 37: 761–800

    CAS  PubMed  Google Scholar 

  5. Fujimura A, Ohira H, Ohashi K, Ebihara A (1992) Chronopharmacology of probucol in mice. Japan J Pharmacol 59: 121–124

    CAS  Google Scholar 

  6. Tawara K, Tomikawa M, Abiko Y (1986) Mode of action of probucol in reducing serum cholesterol in mice. Japan J Pharmacol 40: 123–133

    CAS  Google Scholar 

  7. Myant NB, Mitropoulos KA (1977) Cholesterol 7α-hydroxylase. J Lipid Res 18: 135–153

    CAS  PubMed  Google Scholar 

  8. Noshiro M, Nishimoto M, Okuda K (1990) Rat liver cholesterol 7α-hydroxylase. J Biol Chem 265: 10036–10041

    CAS  PubMed  Google Scholar 

  9. Nakano A, Tietz PS, LaRusso NF (1990) Circadian rhythms of biliary protein and lipid excretion in rats. Am J Physiol 258: G653-G659

    CAS  PubMed  Google Scholar 

  10. Pooler PA, Duane WC (1988) Effects of bile acid administration on bile acid synthesis and its circadian rhythm in man. Hepatology 8: 1140–1146

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun, 329-04, Tochigi, Japan

    A. Fujimura M. D., K. Ohashi & A. Ebihara

Authors
  1. A. Fujimura M. D.
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  2. K. Ohashi
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  3. A. Ebihara
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Fujimura, A., Ohashi, K. & Ebihara, A. Time-dependent change in the effect of probucol in subjects with elevated cholesterol. Eur J Clin Pharmacol 43, 299–301 (1992). https://doi.org/10.1007/BF02333027

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  • DOI: https://doi.org/10.1007/BF02333027

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