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Comparative bioavailability of two different rectal preparations of piroxicam in man

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Summary

A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study.

No significant difference was found in the pharmacokinetic parameters [AUC(0–72 h), AUC, Cmax, t1/2β calculated from plasma concentration time curves, indicating that the two preparations were bioequivalent.

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Authors and Affiliations

  1. Department of Pharmacokinetics, EGIS Pharmaceuticals, P.O. Box 100, H-1475, Budapest, Hungary

    S. Benkö, G. Grézal, É. Nagy & I. Klebovich

Authors
  1. S. Benkö
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  2. G. Grézal
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  3. É. Nagy
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  4. I. Klebovich
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Benkö, S., Grézal, G., Nagy, É. et al. Comparative bioavailability of two different rectal preparations of piroxicam in man. Eur J Clin Pharmacol 43, 315–317 (1992). https://doi.org/10.1007/BF02333031

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  • DOI: https://doi.org/10.1007/BF02333031

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