Summary
We have evaluated the effect of prostaglandin E1(PGE1) on renal function after cardiac surgery with cardiopulmonary bypass in 20 patients, ten of whom received 0.02 μg·kg−1·min−1 of PGE1 by infusion into the oxygenator during bypass; ten patients served as controls.
Serum β2-microglobulin fell significantly and urine β2-microglobulin increased significantly after surgery in both groups. Urine N-acetyl-β-D-glucosaminidase was high after surgery in both groups, but it was significantly lower in the PGE1 group. Free water clearance fell significantly on the 1st, 3rd, and 5th postoperative days compared with preoperative values in the control but not in the PGE1 group.
These results suggest that PGE1 may prevent renal dysfunction after cardiopulmonary bypass.
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References
Kawamura M, Minamikawa O, Yokochi H, Maki S, Yasuda T, Mizukawa Y (1982) Hemodynamic effects of prostaglandin E1 during cardiopulmonary bypass in infants and children. J Surg 12: 19–25
Addonizo VP Jr, Macarak EJ, Niewiarowski S, Colman RW, Edmunds LH Jr (1979) Preservation of human platelets with prostaglandin E1 during in vitro simulation of cardiopulmonary bypass. Circ Res 44: 350–357
Bhat JG, Gluck M, Lowenstein J, Baldwin DS (1976) Renal failure after open heart surgery. Ann Intern Med 84: 677–682
Hilberman M, Myers BD, Carrie BJ, Derby G, Jaminson RL, Stinson EB (1979) Acute renal failure following cardiac surgery. J Thorac Cardiovasc Surg 77: 880–888
Menashe PI, Ross SA, Gottlieb JE (1988) Acquired renal insufficiency in critically ill patients. Crit Care Med 16: 1106–1109
Dunn MJ, Hood VL (1977) Prostaglandins and kidney. Am J Physiol 233: F169–184
Carlson LA, Eriksson I (1973) Femoral artery infusion of prostaglandin E1 in severe peripheral vascular disease. Lancet I: 155–156
Abel RM, Buckley MJ, Austen WL, Barnett GO, Beck CH, Fisher JE (1973) Etiology, incidence and prognosis of renal failure following cardiac operations. J Thorac Cardiovasc Surg 71: 323–333
Berggard I, Bearn AG (1968) Isolation and properties of low molecular weight B2-microglobulin occurring in human biological fluids. J Biol Chem 243: 4095–4103
Kunin CM, Chesney RW, Craig WT, England AC, DeAngelis C (1978) Enzymuria as a marker of renal injury and disease. Studies of N-Acetyl-beta-glucosaminidase in the general population and in patients with renal disease. Pediatrics 62: 751–760
Mogensen CE, Solling K (1977) Studies on renal tubular protein reabsorption: partial and near complete inhibition by certain amino acids. Scand J Clin Lab Invest 37: 477–486
Peterson PA, Evrin PE, Berggard I (1969) Differentiation of glomerular, tubular, and normal proteinuria: determination of urinary excretion of beta2-microglobulin, albumin and total protein. J Clin Invest 48: 1189–1198
Braren V, Goddard J, Brill AB, Touya JJ (1979) Beta-2-microglobulin as renal diagnostic agent. Urology 13: 624–628
Heimann T, Brau S, Sakurai H, Peirce EC (1976) Urinary osmolal changes in renal dysfunction following open heart operations. Ann Thorac Surg 22: 44–49
Landes RG, Lillehei RC, Lindsay WG, Nicoloff DM (1976) Free water clearance and early recognition of acute renal insufficiency after cardiopulmonary bypass. Ann Thorac Surg 22: 41–43
Gailiunas P Jr, Chawla R, Lazarus JM, Cohn L, Sanders J, Merrill JP (1980) Acute renal failure following cardiac operations. J Thorac Cardiovasc Surg 79: 241–243
Utley JR, Watchel C, Cain RB, Spaw EA, Collins JC, Stephen DB (1981) Effects of hypothermia, hemodilution, and pump oxygenation on organ water content, blood flow and oxygen delivery, and renal function. Ann Thorac Surg 31: 121–133
Goto F, Otani E, Kato S, Fujita T (1982) Prostaglandin E1 as a hypotensive drug during general anaesthesia. Anaesthesia 37: 530–535
Gorman RR (1978) Prostaglandins, thromboxanes and prostacyclin. In: Rickenberg HV (ed) Biochemistry and mode of action of hormones, part II. University Park Press, Baltimore, pp 81–107
Sczeklik J, Dubiel JS, Mieczyslaw M, Pyzik Z, Krol R, Horzela T (1978) Effects of prostaglandin E1 on pulmonary circulation in patients with pulmonary hypertension. Br Heart J 40: 1397–1401
Lum GM (1977) In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin. J Clin Invest 59: 8–13
Grantham JJ, Orloff J (1968) Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′, 5′-monophosphate and theophylline. J Clin Invest 47: 1154–1161
Beck NP, Kaneko T, Zor U, Field JB, Davis BB (1971) Effects of vasopressin and prostaglandin E1 on the adenyl cyclase-cyclic 3′, 5′-adenosine monophosphate system of the renal medulla of the rat. J Clin Invest 50: 2461–2465
De Torrente A, Miller PD, Cronin RE (1978) Effects of furosemide and acetylcholine in norepinephrine induced acute renal failure. Am J Physiol 235: F131–136
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Abe, K., Fujino, Y. & Sakakibara, T. The effect of prostaglandin E1 during cardiopulmonary bypass on renal function after cardiac surgery. Eur J Clin Pharmacol 45, 217–220 (1993). https://doi.org/10.1007/BF00315386
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DOI: https://doi.org/10.1007/BF00315386