Abstract
Objective: The correlations between steady-state plasma concentrations of mianserin and its active metabolite desmethylmianserin and those of trazodone and its active metabolite m-chlorophenylpiperazine (m-CPP) were examined in 19 depressed patients.
Methods: Ten patients received first mianserin (30 mg per day) and second trazodone (150 mg per day), while 9 patients received these treatments in the opposite sequence, with at least 2-week intervals between the two phases. Blood was sampled at steady state, 1–3 weeks after initiation of each treatment. Plasma concentrations of mianserin, the separate enantiomers S(+)- and R(−)-mianserin, desmethylmianserin, trazodone and m-CPP were measured by means of high-performance liquid chromatography.
Results: There was a significant correlation between steady-state plasma concentrations of trazodone and total mianserin (r = 0.59) or S(+)-mianserin (r = 0.57), but not R(−)-mianserin (r = 0.33).
Conclusion: The present study thus suggests that the metabolic capacity of mianserin, especially the more active S(+)-enantiomer, and that of trazodone correlate to each other. This finding supports the previous suggestions that cytochrome P4502D6 is involved in the metabolism of mianserin and trazodone.
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Received: 14 March 1997 / Accepted in revised form: 21 August 1997
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Otani, K., Tybring, G., Mihara, K. et al. Correlation between steady-state plasma concentrations of mianserin and trazodone in depressed patients. E J Clin Pharmacol 53, 347–349 (1998). https://doi.org/10.1007/s002280050391
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DOI: https://doi.org/10.1007/s002280050391