Summary
The buccal absorption of procainamide was studied in 4 normal, male volunteers over a pH range of 5–11. In another investigation the same 4 volunteers collected their urine for 24 h after taking 250 mg of procainamide hydrochloride orally on 3 separate occasions, during which urine pH was uncontrolled, acidified by ammonium chloride ingestion or alkalinised by sodium bicarbonate ingestion. The procainamide remaining after buccal absorption and present in the urine samples was determined spectrophotometrically. It was found that neither the buccal absorption nor the renal excretion of procainamide was substantially altered by changes in pH.
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References
Beckett, A.H., Rowland, M.: Urinary excretion kinetics of amphetamine in man. J. Pharm. Pharmacol.17, 628–639 (1965)
Beckett, A.H., Triggs, E.J.: Buccal absorption of basic drugs and its application as anin vivo model of passive drug transfer through lipid membranes. J. Pharm. Pharmacol.19, 31S-41S (1967)
Büchi, J., Cordes, G., Perlia, X.: Beziehungen zwischen den physikalischchemischen Eigenschaften und der lokalanästhetischen Wirkung einiger Procain-Analogue. Arzneimittel-Forsch.14, 161–169 (1964)
Dreyfuss, J., Bigger, J.T., Cohen, A.I., Schreiber, E.C.: Metabolism of procainamide in rhesus monkey and man. Clin. Pharmacol. Ther.13, 366–371 (1972)
Hicks, D.C.: The buccal absorption of some β-adrenoceptor blocking drugs. Brit. J. Pharmacol.47, 680P (1973)
Hydén, S.: A turbidimetric method for the determination of higher polyethylene glycols in biological materials. Ann. roy. agric. Coll. Sweden22, 139–145 (1955)
Kaye, C.M., Robinson, D.G., Turner, P.: The influence of pH on the renal excretion of practolol and propranolol. Brit. J. Pharmacol.49, 155P (1973)
Koch-Weser, J., Klein, S.W.: Procainamide dosage schedules, plasma concentrations and clinical effects. J. Amer. med. Ass.215, 1454–1460 (1971)
Mark, L.C., Kayden, H.J., Steel, J.M., Cooper, J.R., Berlin, I., Rovenstine, E.A., Brodie, B.B.: The physiological deposition and cardiac effects of procainamide. J. Pharmacol. exp. Ther.102, 5–15 (1951)
Milne, M.D., Scribner, B.H., Crawford, M.A.: Non-ionic diffusion and excretion of weak acids and bases. Amer. J. Med.24, 709–729 (1958)
Torretti, J., Weiner, I.M., Mudge, G.H.: Renal tubular secretion and reabsorption of organic bases in the dog. J. clin. Invest.41, 793–804 (1962)
Weily, H.S., Genton, E.: Pharmacokinetics of procainamide. Arch. intern. Med.130, 366–369 (1972)
Weiner, I.M., Mudge, G.H.: Renal tubular mechanisms for excretion of organic acids and bases. Amer. J. Med.36, 743–762 (1964)
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Meyer, W., Kaye, C.M. & Turner, P. A study of the influence of pH on the buccal absorption and renal excretion of procainamide. Eur J Clin Pharmacol 7, 287–289 (1974). https://doi.org/10.1007/BF00560346
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DOI: https://doi.org/10.1007/BF00560346