Summary
Plasma indomethacin levels have been compared in 10 subjects following 100 mg of indomethacin from two different formulations, with similar disintegration and dissolution profiles. In four of these ten subjects plasma indomethacin levels were estimated after pretreatment with, and concurrent administration of, a buffered aspirin. The percentage of protein binding of indomethacin in the presence of salicylate was also estimated. No significant differences between peak plasma indomethacin levels with or without buffered aspirin were detected, but the rate of indomethacin absorption as shown by plasma levels, was significantly increased by pretreatment with and concurrent administration of, buffered aspirin. This was associated with a marked increase in side effects.
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Champion, G.D., Paulus, H.E., Mongan, E., Okun, R., Pearson, C.M., Sarkissan, E.: The effect of aspirin on serum indomethacin. Clin.Pharmacol.Ther.13 (2), 239–244 (1972)
Holt, L.P.J., Hawkins, C.F.: Indomethacin: Studies of absorption and of the use of indomethacin suppositories. Brit.med.J.1965 I 1354–1356
Lange, W.E., Bell, S.A.: Fluorometric determination of acetylsalicylic acid and salicylic acid in blood. J.pharm.Sci.55 386–389 (1966)
Kuna, S.: The pH of gastric juice in the normal resting stomach. Arch.Int.Pharmacodyn.151 79–97 (1964)
Hucker, H.B., Zacchei, A.G., Cox, S.V., Brodie, D.A.B., Cantwell, N.H.R.: Studies on the absorption, distribution, and excretion of indomethacin in various species. J.Pharmacol.exp.Ther.153 237–249 (1966)
McArthur, J.N., Daskins, P.D., Smith, M.J.H.: The binding of indomethacin, salicylate and phenobarbitone to human whole bloodin vitro. J.Pharmacol. (Kyoto)23 32–36 (1971)
Hvidberg, E., Lansen, H.H., Jansen, J.A.: Indomethacin: plasma concentrations and protein binding in man. Europ.J.clin.Pharmacol.4 119–124 (1972)
Norcross, B.M.: Treatment of connective tissue disease with new non-steroidal compound (indomethacin). Arthr. and Rheum.6 290 (1963)
Catoggio, P.M., Centurion, A., Alberti, H., Roldan, H., Canepa, L.: Indomethacin in rheumatoid arthritis: properties, side effects. Arthr. and Rheum.7 300 (1964)
Rothermich, N.O.: Indomethacin: new pharmacologic approach to management of rheumatoid disease. Arthr. and Rheum.6 295 (1963)
Wanka, J., Jones, L.I., Wood, P.H.N., Dixon, A.St.J.: Indomethacin in rheumatic diseases: controlled clinical trial. Ann.Rheumat.Dis.23 218–225 (1964)
Hart, F.D., Boardman, P.L.: Indomethacin and phenylbutazone: comparison. Brit.med.J.1965 II 1281–1284
Cooperating Clinics Committee of the American Rheumatism Association: A three-months trial of indomethacin in rheumatoid arthritis, with special reference to analysis and inference. Clin.Pharmacol.Ther.8 11–37 (1967)
Jeremy, R., Towson, J.: Interaction between aspirin and indomethacin in the treatment of rheumatoid arthritis. Med.J.Aust.2 127–129 (1970)
Van Arman, C.G., Nuss, G.W.: Interaction of aspirin with antiinflammatory drugs. Pharmacologist12 202 (1970)
Mielens, Z.E.,et al.: Interaction of aspirin with nonsteroidal antiinflammatory drugs in rats. J.Pharm.Pharmacol.20 567–569 (1968)
Mainland, D.: Clin.Pharmacol.Ther.8 11–37 (1967)
Donnelly, P., Lloyd, K., Campbell, H.: Indomethacin in rheumatoid arthritis: an evaluation of its anti-inflammatory and side effects. Brit.med.J.1967 I 69–75
Melmon, K.L.: Medical Staff Conference: The Clinical Pharmacology of Salicylates. California Medicine110 410–422 (1969)
Emori, W., Paulus, H.E., Bluestone, R., Pearson, C.M.: The pharmacokinetics of indomethacin in serum. Clin.Pharmacol.Ther.14 (1), 134 (1973)
Ambre, J.J., Fisher, L.J.: Effect of coadminis-stration of aluminium and magnesium hydroxides on absorption of anticoagulants in man. Clin.Pharmacol.Ther.14 (2), 231–237 (1973)
Barzilay, R., Hersey, J.: Dissolution rate measurement by an automated dialysis method. J.Pharm.Pharmacol.20S 232S-238S (1968)
Anonymous: Drug interactions that can affect your patients. In: Patients care, pp. 1–23. New York: Miller and Fink Publishing Corp. 1967
Azarnoff, D., Hurwitz, A.: Drug interactions. In: Pharmacology for physicians, pp. 1–7. Philadelphia: W.B. Saunders Co. 1970
Goldstein, A., Aronow, L., Kalman, S.: Principles of drug actions, pp. 320. New York: Harper & Row 1968
Hussar, D.: Oral anticoagulants-their interactions. J.Amer.pharm.Ass.10 78–83 (1970)
McCallister, J., Chin, T., Lach, J.: Diffuse reflectance studies of solid-solid interactions. IV. Interaction of bishydroxycoumarin, furosemide and other medicinal agents with various adjuvants. J.pharm.Sci.59 1286–1289 (1970)
Zupko, A.G.: A practical guide to drug interactions, pp. 52–73. In: Resident and Staff Physician, March 1970
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Garnham, J.C., Raymond, K., Shotton, E. et al. The effect of buffered aspirin on plasma indomethacin. Eur J Clin Pharmacol 8, 107–113 (1975). https://doi.org/10.1007/BF00561558
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DOI: https://doi.org/10.1007/BF00561558