Summary
Plasma protein binding capacity for phenylbutazone has been studied in 4 patients with acute renal failure. There was an initial important decrease in binding capacity, which gradually returned to normal with improvement of renal function.
Similar content being viewed by others
References
Reidenberg, M.M., Affrime, M.: Influence of disease on binding of drugs to plasma proteins. Ann. N. Y. Acad. Sci.226, 115–126 (1973)
Andreasen, F.: Protein binding of drugs in plasma from patients with acute renal failure. Acta pharmacol. (KbH.)32, 417–429 (1973)
Andreasen, F.: The effect of dialysis on the protein binding of drugs in the plasma of patients with acute renal failure. Acta pharmacol. (KbH.)34, 284–294 (1974)
Andreasen, F., Jakobsen, P.: Determination of furosemide in blood plasma and its binding to proteins in normal plasma and in plasma from patients with acute renal failure. Acta pharmacol. (Kbh.)35, 49–57 (1974)
Campion, D.S.: Decreased drug binding by serum albumin during renal failure. Toxicol. appl. Pharmacol.25, 391–397 (1973)
Reidenberg, M.M., Odar-Cederlöf, I., von Bahr, C., Borga, O., Sjöqvist, F.: Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function. New Engl. J. Med.285, 264–267 (1971)
Anton, A.H., Corey, W.T.: Interindividual differences in the protein binding of sulfonamides: The effect of disease and drugs. Acta pharmacol. (Kbh.)29, 134–151 (1971)
Dromgoole, S.H.: The effect of haemodialysis on the binding capacity of albumin. Clin. chim. Acta46, 469–472 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mussche, M.M., Belpaire, F.M. & Bogaert, M.G. Plasma protein binding of phenylbutazone during recovery from acute renal failure. Eur J Clin Pharmacol 9, 69–71 (1975). https://doi.org/10.1007/BF00613431
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00613431