Summary
In view of a previous report suggesting an increased metabolism of the beta-blocking agent pindolol with decreasing renal function in man, the relationship between renal function and the elimination kinetics of pindolol has been re-examined. There is a statistically significant positive correlation between the renal clearances of pindolol and creatinine but there is no correlation between the non-renal clearance of pindolol and the renal clearance of creatinine. Thus, there is no evidence of an increased metabolism (non-renal clearance) of pindolol with decreasing renal function.
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References
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Øie, S., Levy, G. Relationship between renal function and elimination kinetics of pindolol in man. Eur J Clin Pharmacol 9, 115–116 (1975). https://doi.org/10.1007/BF00614006
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DOI: https://doi.org/10.1007/BF00614006