Summary
Sixty-eight patients with malignant melanoma were examined by CCT and the findings analyzed. Cerebral metastases were detected in 19 patients. Meningiomas were found in three patients, one with neurological symptoms and two without. Typical metastases less than 10 mm in diameter were located superficially in the grey matter, regular, homogenous, hyperdense, with no edema. Extensive peripheral edema was often associated with metastases measuring more than 10 mm. CCT revealed cerebral metastases in 6 (13%) of 46 asymptomatic patients. The metastases measured less than 10 mm in four and less than 20 mm in two of these patients. Scintigraphy was falsly negative in six patients with metastases smaller than 10 mm. Therefore, CCT is the method of choice for screening asymptomatic patients. Angiography may be of value in the differentiation between meningioma and melanoma metastases.
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References
Enzmann DR, Kramer R, Norman D, Pollock J (1978) Malignant melanoma metastatic to the central nervous system. Radiology 127:177–180
Amer MH, Al-Sarraf M, Baker LH, Vaitkevicius VK (1978) Malignant melanoma and central nervous system metastases. Incidence, diagnosis, treatment and survival. Cancer 42:660–668
De Vita VT, Fisher R (1976) Natural history of malignant melanoma as related to therapy. Cancer Treat Rep 60:153–157
Ahmann DL, Hahn RG, Bisel HF (1974) Evaluation of 1-(2-chloro-ethyl-3-4-methyl-cyclothecyl)-1-nitros-urea (methyl-CCNU, NSC 95441) versus combined imidazole carboxamide (NSC-45388) and vincristine (NSC 67574) in palliation of disseminated malignant melanoma. Cancer 33:615–618
Cowan DH, Bergsagel DE (1971) Intermittent treatment of metastatic malignant melanoma with high dose (3.3-dimethyl-1-triazeno) imidazole-4-carboxamide (NSC-45388). Cancer Chemother Rep 55:175–181
Hafström LO, Jönsson PE (1981) Symptoms of occult brain metastases initiated by systemic dacarbazin (DTIC-DOME) therapy in melanoma patients. Clin Oncol (in press)
Butler AR, Leo JI, Boyd AD, Kricheff II (1979) The value of routine cranial computed tomography in neurologically intact patients with carcinoma of the lung. Radiology 131:399–401
Ginaldi S, Wallace S, Shalen P, Suma M, Handel S (1980) Cranial computed tomography of malignant melanoma. Am J Neuroradiol 1:531–535
Wood M, White R, Kernohan J (1957) One hundred intracranial meningeomas found incidentally at necropsy. J Neuropathol Exp Neurol 16:337–340
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Holtås, S., Cronqvist, S. Cranial computed tomography of patients with malignant melanoma. Neuroradiology 22, 123–127 (1981). https://doi.org/10.1007/BF00346752
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DOI: https://doi.org/10.1007/BF00346752