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A quantitative study of physiological cerebral atrophy with aging

A statistical analysis of the normal range

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Summary

A new method of discriminating pathological cerebral atrophy from physiological atrophy during aging is reported. The authors advocate a pixel counting method using a minicomputer for the quantitative measurement of cerebral atrophy. Five hundred cases were studied with this quantitative method and the normal range of the physiological atrophy was determined statistically. In order to estimate the degree of cerebral atrophy easily, the conventional linear measurement methods were compared with the pixel counting method using multivariant analysis, and a simple formula for the calculation of the degree of cerebral atrophy is proposed. Using this formula and the normal range, pathological cerebral atrophy is easily detectable.

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Authors and Affiliations

  1. Department of Neurosurgery, Saitama Medical Center, Saitama, Japan

    K. Nagata

  2. Department of Neurosurgery, Kanto Rosai Hospital, Kawasaki, Japan

    N. Basugi

  3. Department of Neurosurgery, Mitsui Memorial Hospital, Tokyo, Japan

    T. Fukushima

  4. Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    T. Tango, I. Suzuki, T. Kaminuma & S. Kurashina

Authors
  1. K. Nagata
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  2. N. Basugi
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  3. T. Fukushima
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  4. T. Tango
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  5. I. Suzuki
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  6. T. Kaminuma
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  7. S. Kurashina
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Nagata, K., Basugi, N., Fukushima, T. et al. A quantitative study of physiological cerebral atrophy with aging. Neuroradiology 29, 327–332 (1987). https://doi.org/10.1007/BF00348909

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  • DOI: https://doi.org/10.1007/BF00348909

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