Summary
Two cases of histologically proven primary cerebral malignant lymphoma were examined serially with positron emission tomography (PET) using11C-methyl-l-methionine (11C Met). Lesions delineated by11C Met accumulation extended beyond enhancing areas on either X-ray computed tomography (CT) or magnetic resonance imaging. High uptake of11C Met accurately showed biologically active and residual tumours, at a time when disappearance of a contrast-enhancing lesion on CT seemed to indicate involution. PET provides valuable information on the extent of tumour and assessment of radiotherapy in malignant lymphoma.
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References
Mineura K, Sasajima T, Suda Y, Kowada M, Shishido F, Uemura K (1989) Early and accurate detection of primary cerebral glioma with interfibrillary growth using11C-l-methionine positron emmission tomography. J Med Imaging 33:192–196
Derlon JM, Bourdet C, Bustany P, Chatel M, Theron J, Darcel F, Syrota A (1989) [11C]l-methionine uptake in gliomas. Neurosurgery 25:720–728
Erickson K, Lilja A, Bergstrom M, Collins P, Eriksson L, Ehrin E, Holst H von, Lundqvist H, Langstrom B, Mosskin M (1985) Positron emission tomography with ([11C]methyl)-l-methionine, [11C]d-glucose, and [68Ga]EDTA in supratentorial tumors. J Comput Assist Tomogr 9:683–689
Hochberg FH, Millar DC (1988) Primary central nervous system lymphoma. J Neurosurg 68:835–853
Jiddane M, Nicoli F, Diaz P, Bergvall U, Vincentell F, Hassoun J, Salamon G (1986) Intracranial malignant lymphoma. J Neurosurg 65:592–599
Mendenhall NP, Thar TL, Agee OF, Harty-Golder B, Ballinger WE, Millon RR (1983) Primary lymphoma of the central nervous system: computerized tomography scan characteristics and treatment results for 12 cases. Cancer 52:1993–2000
Murray K, Kin L, Cox J (1986) Primary lymphoma of the central nervous system: results of treatment of 11 cases and review of the literature. J Neurosurg 65:600–607
Grant JW, Gallagher PJ, Jones DB (1986) Primary cerebral lymphoma: a histologic and immunohistochemical study of six cases. Arch Pathol Lab Med 110:897–901
Newell GR, Cabanillas FG, Hagemeister FJ, Butler JJ (1987) Incidence of lymphoma in the US classified by the Working Formulation. Cancer 59:857–861
Baumgartner JE, Rachlin JR, Beckstead JH, Meeker TC, Levy RM, Wara WM, Rosenblum ML (1990) Primary central nervous system lymphomas: natural history and response to radiation therapy in 55 patients with acquired immunodeficiency syndrome. J Neurosurg 73:206–211
Leibel SA, Sheline GE (1987) Radiation therapy for neoplasms of the brain. J Neurosurg 66:1–22
Niibe H, Tamaki Y, Watanabe S, Masaki N, Horiuchi J, Hayabuchi N, Kaneda K, Morita K (1988) Therapeutic results of primary cerebral malignant lymphoma of the brain (in Japanese). Jpn J Cancer Clin 34:651–667
Kuwabara Y, Ichiya Y, Otsuka M, Miyake Y, Gunasekawa R, Hasuo K, Masuda K, Takeshita I, Fukui H (1988) High [18F]FDG uptake in primary cerebral lymphoma: a PET study. J Comput Assist Tomogr 12:47–48
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Sawataishi, J., Mineura, K., Sasajima, T. et al. Effects of radiotherapy determined by11C-methyl-l-methionine positron emission tomography in patients with primary cerebral malignant lymphoma. Neuroradiology 34, 517–519 (1992). https://doi.org/10.1007/BF00598964
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DOI: https://doi.org/10.1007/BF00598964