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Unusual pattern of leukoencephalopathy after morphine sulphate intoxication

  • PAEDIATRIC NEURORADIOLOGY
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Abstract

We report a 14-year-old girl with an unusual pattern of leukoencephalopathy after intentional intoxication with morphine sulphate tablets. Toxicological analysis showed exceedingly high levels of morphine and its metabolites. MRI disclosed a leukoencephalopathy with high signal from the centrum semiovale, corpus callosum and cerebellar white matter on T2-weighted images. These findings could be only partially explained by a hypoxic-ischaemic event; neurotoxic effects must be considered in this atypical leukoencephalopathy.

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Authors and Affiliations

  1. Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97 080 Würzburg, Germany e-mail:KINK106@mail.uni-wuerzburg.de Tel.: + 49-9 31-2 01-37 60 Fax: + 49-9 31-2 01-37 20, , , , , , DE

    R. Nanan, H. B. von Stockhausen & B. Petersen

  2. Department for Neuroradiology, University of Würzburg, Germany, , , , , , DE

    L. Solymosi & M. Warmuth-Metz

Authors
  1. R. Nanan
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  2. H. B. von Stockhausen
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  3. B. Petersen
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  4. L. Solymosi
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  5. M. Warmuth-Metz
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Additional information

Received: 3 August 1999 Accepted: 3 April 2000

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Nanan, R., von Stockhausen, H., Petersen, B. et al. Unusual pattern of leukoencephalopathy after morphine sulphate intoxication. Neuroradiology 42, 845–848 (2000). https://doi.org/10.1007/s002340000442

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  • DOI: https://doi.org/10.1007/s002340000442

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