Skip to main content
Log in

Zinc and cadmium concentration in prostatic carcinoma of different histological grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH)

  • Originals
  • Published:
Urological Research Aims and scope Submit manuscript

Summary

Zn and Cd concentrations in tissue of normal prostate gland, BPH and prostatic carcinoma of different histological grades have been determined by atomic absorption spectrometry before therapy. We found a distinct biological anatagonistic effect between Zn and Cd in the human prostate gland. We have seen an increasing amount of Zn in BPH, but a decrease in prostatic cancer. In contrast, we found a continuous increase of cadmium concentration from the normal prostate via BPH through carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Aughey E, Scott R, King PC, East BW, Harris IA and Baldy (1975) The distribution and retention of cadmium 115 m in the rat following injection in the prostate. Br J Urol 47:185–191

    Google Scholar 

  2. Bertrand G, Vladesco R (1921) Intervention probable du zinc dans les phaenomens de fecondation chez les animaux vertebrates. CR Acad Sci (Paris) 173:176

    Google Scholar 

  3. Daniel O, Haddad F, Prout G, Whitemore WF (1956) Some observations on distribution of radioactive zinc in prostatic and other human tissues. Br J Urol 28:271–278

    Google Scholar 

  4. Gunn SA, Gould TC, Anderson WAD (1961) Competition of cadmium for zinc in rat testes and dorsolateral prostate. Acta Endocrinol 37:24–30

    Google Scholar 

  5. Johnson AD, Walther GP (1970) Early actions of cadmium in the rat and domestic fowl testis. J Repod Fertil 23:463–468

    Google Scholar 

  6. Kerr WK, Kerrestici AG, Mayoh H (1960) The distribution of zinc within the prostate gland. Cancer 13:550–554

    Google Scholar 

  7. Kipling MD, Waterhouse JAH (1967) Cadmium and prostatic carcinoma. Lancet 1:790–791

    Google Scholar 

  8. Kolonel LN (1976) Association of cadmium with renal cancer. Cancer 37:1782–1787

    Google Scholar 

  9. Krieg M (1975) Physiologie and Pathophysiologie der Prostata. Thieme, Stuttgart, pp 53–61

    Google Scholar 

  10. Lo MC, Hall T, Whitmore WF (1960) Cancer 13:401

    Google Scholar 

  11. Malcolm D (1972) Potential carcinogenic effect of cadmium in animals and man. An Occup Hyg 15:33–37

    Google Scholar 

  12. Mawson CA, Ficher MJ (1952) Occurence of zinc in human prostate gland. Can J Med Sci 30:336

    Google Scholar 

  13. Moger WJ, Geschwind J (1972) The action of prolactin on the sex accessory glands of the male rat. Proc Soc Exp Biol (NY) 14:1017

    Google Scholar 

  14. Oestergaard K (1978) Cadmium concentration in relation to smoking habits and blood pressure. Acta Med Scand 203:379–383

    Google Scholar 

  15. Oestergaard K (1977) Cadmium and hypertension. Lancet I:677

    Google Scholar 

  16. Copius-Peereboom JHJ (1981) Toxic effects of cadmium to animals and man. Toxicol Environ Chem Rev 4:67–178

    Google Scholar 

  17. Piscator M (1981) Environ Health Perspect 40:107–120

    Google Scholar 

  18. Pool MZ (1981) Exposure and health effects of cadmium. Toxicol Environ Chem Rev 4:179–203

    Google Scholar 

  19. Prout JR, Sierp M (1959) Radioactive zinc in the prostate. JAMA 169:1703

    Google Scholar 

  20. Reed MJ, Stitch SR (1973) Endocrinol 58:405–419

    Google Scholar 

  21. Schenck B (1975) Physiologie und Pathologie der Prostata. Thieme, Stuttgart, pp 11–24

    Google Scholar 

  22. Schoonees R, de Klerk JW, Murphy GP (1969) Correlation of prostatic bloodflow with 45 zinc activity in intact, castrated and testosterone treated baboons. Invest Urol 6:476

    Google Scholar 

  23. Vallee BZ (1959) Biochemistry, physiology and pathology of zinc. Phys Rev 39:443–458

    Google Scholar 

  24. de Voogt P, v Hattem B, Feenstra JF, Copius-Peereboom JW (1980) Exposure and health effects of cadmium. Toxicol. Environ Chem Rev 3:89–109

    Google Scholar 

  25. Whitmore WF (1963) Comments on zinc in the human and canine prostate. Nat Cancer Inst Monogr 12:337–340

    Google Scholar 

  26. Wynder EL, Kiyohiko M, Whitmore WF (1971) Epidemology of cancer of the prostate. Cancer 28:344–360

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Feustel, A., Wennrich, R., Steiniger, D. et al. Zinc and cadmium concentration in prostatic carcinoma of different histological grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH). Urol. Res. 10, 301–303 (1982). https://doi.org/10.1007/BF00255877

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00255877

Key words

Navigation