Summary
Cadmium injection in rats affects the genito-urinary system. The renal effects are generally considered to be mainly tubular. Light microscopy of 29 specimens confirms cellular damage in the glomeruli with changes in glomerular capillaries. Electron microscopic changes in the glomeruli confirm changes in the podocytes, thickening of the basement lamina, the occurrence of electron dense deposits in association with the capillary endothelium with platelet and polymorphonuclear cell accumulations which suggests opening of the endothelial junction of the glomerular vessels.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aughey, E., Scott, R., King, P. C., East, B. W., Harris, I. A., Boddy, K.: The distribution and retention of cadmium 115m in the rat following injection into the prostate. British Journal of Urology 47, 185 (1975)
Bonnell, J. A.: Emphysema and proteinuria in men casting copper-cadmium alloys. British Journal of Industrial Medicine 12, 181 (1955)
Bonnell, J. A., Ross, J. H., King, E.: Renal lesions in experimental cadmium poisoning. British Journal of Industrial Medicine 17, 69 (1960)
Castano, P.: Chronic intoxication by cadmium experimentally induced in rabbits. A study of kidney ultrastructure. Pathologia et Microbiologia 37, 380 (1971)
Castano, P., Vigliani, E. C.: Cadmium nephropathy: ultrastructural observations (horse radish peroxidase). Journal of Occupational Medicine 14, 125 (1972)
Caulfield, J. P., Reid, J. J., Farquhar, M. E.: Alterations of the glomerular epithelium in acute aminonucleoside nephrosis. Evidence for the formation of occluding junctions and epithelial cell detachment. Laboratory Investigation 34, 43 (1976)
Creeth, J. M., Kekwick, R. A., Flynn, F. V., Harris, H., Robson, E. B.: An ultracentrifuge study of urine proteins with particular reference to the proteinuria of renal tubular disorders. Clinica Chimica Acta 8, 406 (1963)
Friberg, L.: Proteinuria and kidney injury among workman exposed to cadmium and nickel dust. Journal of Industrial Hygiene and Toxicology 30, 32 (1948a)
Friberg, L.: Proteinuria and emphysema among workers exposed to cadmium and nickel in a storage battery plant. Proceedings of the International Congress of Industrial Medicine 9, 641 (1948b)
Friberg, L.: Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning. Acta Medica Scandinavica 138, Supp. 240 (1950)
Gabbianni, G., Badonnel, M. C., Mathewson, S. M., Ryan, G. B.: Acute cadmium intoxication. Early selective lesions of endothelial clefts. Laboratory Investigation 30, 686 (1974)
Gunn, S. A., Gould, T. C.: Selective accumulation of Cd115 by the cortex of the rat kidney. Proceedings of the Society for Experimental Biology and Medicine 96, 820 (1957)
Gunn, S. A., Gould, T. C., Anderson, W. A. D.: Specific response of mesenchymal tissue to cancerigenesis by cadmium. Archives of Pathology 83, 493 (1967)
Haddow, A., Roe, F. J. C., Dukes, C. E., Mitchley, B. C. V.: Cadmium neoplasia: sarcomata at the site of injection of cadmium sulphate in rats and mice. British Journal of Cancer 18, 667 (1964)
Kägi, J. H. R., Vallee, B. L.: Metallothionein: a cadmium and zinc containing protein from equine renal cortex. II. Physicochemical properties. Journal of Biological Chemistry 236, 2435 (1961)
Kägi, J. H. R., Vallee, B. L.: Metallothionein: a cadmium and zinc containing protein from equine renal cortex. Journal of Biological Chemistry 235, 3460 (1960)
Luft, J. H.: Improvements in epoxy resin embedding methods. Journal of Biophysical and Biochemical Cytology 9, 409 (1961)
Margoshes, M., Vallee, B. L.: A cadmium protein from equine kidney cortex. Journal of the American Chemical Society 79, 4813 (1957)
Nordberg, G. F., Goyer, R. A., Nordberg, M.: Renal tubular effects of cadmium metallothionein in the mouse. Archives of Pathology 99, 192 (1975)
Parizek, J.: The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. Journal of Endocrinology 15, 56 (1957)
Parizek, J., Zahar, Z.: Effect of cadmium salt on testicular tissue. Nature 177, 1036 (1956)
Perry, H. M., Jr., Erlanger, M. W.: Elevated circulating renin activity in rats following doses of cadmium known to induce hypertension. Journal of Laboratory and Clinical 82, 399 (1973)
Peters, A., Palay, S. L.: The morphology of the lamina A and AI of the dorsal nucleus of the lateral geniculate body of the cat. Journal of Anatomy 100, 451 (1966)
Piscator, M.: Proteinuria in chronic cadmium poisoning. 1. An electrophoretic and chemical study of urinary and serum proteins from workers with chronic cadmium poisoning. Archives of Environmental Health 4, 607 (1962b)
Scott, R., Aughey, E., McLaughlin, I.: Histological and ultrastructural observations on the effects of cadmium on the ventral and dorsolateral lobes of the rat prostate. In: Trace Element Metabolism in Animals-2. Baltimore: University Press 1974
Scott, R., Paterson, P. J., Mills, E. A., McKiroy, A., Fell, G. S., Ottoway, J. M., Husain, F. E. R., Fitzgerald-Finch, O. P., Yates, A. J., Lamont, A., Roxburgh, S.: Clinical and biochemical abnormalities in coppersmiths exposed to cadmium. Lancet 1976 II, 396
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scott, R., Aughey, E. & Sinclair, J. Histological and ultrastructural changes in rat kidney following cadmium injection. Urol. Res. 5, 15–20 (1977). https://doi.org/10.1007/BF00257111
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00257111