Abstract
A patient with primary hyperoxaluria type I in infancy is reported. He had renal insufficiency, but urolithiasis was absent. Demonstration of diffuse nephrocalcinosis by renal ultrasound contributed to early diagnosis. Prolonged survival leads to extensive extrarenal oxalate deposition. Repeated skeletal surveys showed the development and the progression of severe hyperoxaluria-related bone disease. Translucent metaphyseal bands with sclerotic margins, wide areas of rarefaction at the ends of the long bones, and translucent rims around the epiphyses and the tarsal bones were signs of disordered bone growth. Bone density generally increased with time indicating progressive sclerosis due to oxalate deposition in the previously normal bone structure.
References
Leumann EP (1985) Primary hyperoxaluria: an important cause of renal failure in infancy. Int J Pediatr Nephrol 6: 13
de Zegher FE, Wolff ED, v d Heijden AJ, Sukhai RN (1984) Oxalosis in infancy. Clin Nephrol 22: 114
Katzuni E, Sandbank U (1959) Oxalosis. Arch Dis Child 34: 60
Gottlieb RP, Ritter JA (1977) “Flecked retina” — an association with primary hyperoxaluria. J. Pediatr 90: 939
Wilson DA, Wenzl JE, Altshuler GP (1979) Ultrasound demonstration of diffuse cortical nephrocalcinosis in a case of primary hyperoxaluria. AJR 132: 659
Luers PR, Lester PD, Siegler RL (1980) CT demonstration of cortical nephrocalcinosis in congenital oxalosis. Pediatr Radiol 10: 116
Brennan JN, Diwan RV, Makker SP, Cromer BA, Bellon EM (1982) Ultrasonic diagnosis of primary hyperoxaluria in infancy. Radiology 145: 147
Morris MC, Chambers TL, Evans PW, Malleson PN, Pincott JR, Rose GA (1982) Oxalosis in infancy. Arch Dis Child 57: 224
Gilboa N, Largent JA, Urizar RE (1983) Primary oxalosis presenting as anuric renal failure in infancy: diagnosis by X-ray diffraction of kidney tissue. J Pediatr 103: 88
Manz F, Jaschke W, van Kaick G, Waldherr R, Willich E (1980) Nephrocalcinosis in radiographs, computed tomography, sonography and histology. Pediatr Radiol 9: 19
Wiggelinkhuizen J, Fisher RM (1982) Oxalosis of bone. Pediatr Radiol 12: 307
Caffey J (1973) Pediatric X-ray diagnosis, 6th edn. Year Book Medical Publishers, Chicago, p. 1308.
Hug I, Mihatsch JM (1975) Die primäre Oxalosis. Fortschr Röntgenstr 123: 153
Kalifa G, Dossans B, Gagnadoux MF, Sauvegrain J (1979) Aspects radiologiques de l'oxalose. J Radiol 60: 45
Anderson DE, Davidson JK, Catto ME (1983) Case report 227. Skeletal Radiol 9: 266
Breed A, Chesney R, Friedman A, Gilbert E, Langer L, Lattoraca R (1981) Oxalosis-induced bone disease: a complication of transplantation and prolonged survival in primary hyperoxaluria. J Bone Joint Surg [Am] 63: 310
Buri JF (1962) L'oxalose. Helv Paediatr Acta 11: 1
Mathews M, Stauffer M, Cameron EC, Maloney N, Sherard DJ (1979) Bone biopsy to diagnose hyperoxaluria in patients with renal failure. Ann Intern Med 90: 777
Adams NC, Carrera GF, Johnson RP, Latorraca R, Leman J (1982) Calcium-oxalate-crystal-induced bone disease. Am J Kidney Dis 1: 294
McKenna RW, Dehner LP (1976) Oxalosis. An unusual cause of myelophthisis in childhood. Am J Clin Pathol 66: 991
Gherardi G, Poggi A, Sisca S, Calderaro V, Bonucci E (1980) Bone oxalosis and renal osteodystrophy. Arch Pathol Lab Med 104: 105
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Ring, E., Wendler, H., Ratschek, M. et al. Bone disease of primary hyperoxaluria in infancy. Pediatr Radiol 20, 131–133 (1989). https://doi.org/10.1007/BF02010661
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DOI: https://doi.org/10.1007/BF02010661