Abstract
Interaction of the calcium-channel antagonist dihydropyridines (DHPs), lacidipine and nifedipine, with a phospholipid bilayer was studied using 600 ps molecular dynamic simulations. We have constructed a double layer membrane model composed of 42 dimirystoyl-phosphatidylcholine molecules. The DHP molecules locate at about 7 Å from the centre of the membrane, inducing an asymmetry in the bilayer. While lacidipine did not induce significant local perturbations as judged by the gauche-trans isomerisation rate, nifedipine significantly decreased this rate, probably by producing a local rigidity of the membrane in the vicinity of the DHP.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 1 April 1997 / Revised version: 6 October 1997 / Accepted: 5 December 1997
Rights and permissions
About this article
Cite this article
Aiello, M., Moran, O., Pisciotta, M. et al. Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation. Eur Biophys J 27, 211–218 (1998). https://doi.org/10.1007/s002490050127
Issue Date:
DOI: https://doi.org/10.1007/s002490050127