Skip to main content
Log in

Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse

  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

While the role of the H-2 complex in the resistance to virally induced tumors has been extensively studied, little is known about its influence on the development of epithelial tumors of non-viral etiology, although such tumors are most prevalent in humans. Therefore, we analyzed the role of the H-2 complex in susceptibility to mammary tumors induced by hormonal stimulation from heterotopic hypophyseal isografts in H-2 congenic strains from C57BL/10, BALB/c, and 020/A backgrounds. This method of induction allows an assessment of the effect ofH-2 genes on the function of various organs involved in this process. We found that the tumor susceptibility genes map to two segments: PE-S, and to the right of S. The mechanisms by which the H-2 complex affects the induction of mammary tumors in C57BL/10 congenic strains seem to include an influence on several factors involved in the hormonal stimulation, because the susceptible B10 congenic strains have higher plasma levels of prolactin and the H-2 complex also affects the growth of hypophyseal isografts. Their size correlates with tumor development in individual mice in the resistant C57BL/10 congenic strains. We reported previously H-2-dependent differences in levels of the estrogen receptor in hypophysis. For this study, we measured the levels of estrogen receptors in uteri to assess the tissue specificity of this effect of H-2. However, no influence of the H-2 complex on estrogen receptor levels was observed in uteri. Strains from BALB/c and 020 backgrounds developed mammary tumors much earlier than the B10 congenic strains, indicating a strong influence of non-H-2 genes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ashley, R. L., Cardiff, R. D., and Fanning, T. G.: Reevaluation of the effect of mouse mammary tumor virus infection on the BALB/c mouse hyperplastic outgrowth.J Natl Cancer Inst 65: 977–986, 1980

    PubMed  Google Scholar 

  • Bailey, D. W.: Allelic forms of a gene controlling the female immune response to the male antigen in mice.Transplantation 11: 426–428, 1971

    PubMed  Google Scholar 

  • Blair, P. B., Danilows, J. A., and Newly, C.: Genetic regulation of mammary tumor carcinogenesis in mice. In R. G. Crispen (ed.): Cancer: Etiology and Prevention, pp. 141–150, Elsevier, New York, 1983

    Google Scholar 

  • Bonner, J. J. and Tyan, M. L.: Glucocorticoid-induced cleft palate in the mouse: two major histocompatibility complex (H-2) loci with different mechanisms.Genetics 103: 263–276, 1983

    PubMed  Google Scholar 

  • Boot, L. M., Kwa, H. G., and RÖpcke, G.: Hormonal induction of the mouse mammary tumors. In J. Hilgers, M. Sluyser (eds.): Mammary Tumors in the Mouse, pp. 117–200, Elsevier/North Holland, Amsterdam, 1981

    Google Scholar 

  • Demant, P.: Corticosteroid-induced cleft palate: cis interaction of MHC genes and hybrid resistance. iImmunogenetics 22: 183–188, 1985

    PubMed  Google Scholar 

  • Demant, P. and Hart, A. A. M.: Recombinant congenic strains -a new tool for analyzing genetic traits determined by more than one gene.Immunogenetics 24: 416–422, 1986

    PubMed  Google Scholar 

  • Demant, P., Ivanyi, D., Oudshoorn-Snoek, M., Calafat, J., and Roos, M. H.: Molecular heterogeneity of H-2 antigens.Immunol Rev 60: 5–22, 1981

    PubMed  Google Scholar 

  • Demant, P., Oomen, L. C. J. M., and Oudshoorn-Snoek, M.: Genetics of tumor susceptibility in the mouse: major histocompatibility complex and non-MHC genes.Adv Cancer Res 53: 117–179, 1989

    PubMed  Google Scholar 

  • Dux, A.: Sensitivity of the mammary gland to tumor induction. In J. Hilgers, M. Sluyser (eds.): Mammary Tumors in the Mouse, pp. 515–544, Elsevier/North Holland, Amsterdam, 1981

    Google Scholar 

  • Dux, A.: Multiple genetic factors in the MHC and predominant role of D-end in the resistance against C3H-MTV induced mammary tumors.Transplant Proc 15: 2101–2103, 1983

    PubMed  Google Scholar 

  • Dux, A. and Demant, P.: MHC-controlled susceptibility to C3HMTV-induced mouse mammary tumors is predominantly systemic rather than local.Int J Cancer 40: 372–377, 1987

    PubMed  Google Scholar 

  • Dux, A. and Mühlbock, O.: Susceptibility of mammary tissues of different strains of mice to tumor development.J Natl Cancer Inst 40: 1250–1265, 1968

    Google Scholar 

  • Gattoni-Celli, S., Willett, C. G., Rhoads, D. B., Simon, B., Strauss, R. M., Kirsch, K., and Isselbacher, K. J.: Partial suppression of anchorage-independent growth and tumorigenicity in immunodeficient mice by transfection of the H-2 class I gene H-2Ld into a human colon cancer cell line (HCT).Proc Natl Acad Sci USA 85: 8543–8547, 1988

    PubMed  Google Scholar 

  • Hurme, M., Chandler, P. R., Hetherington, C. M., and Simpson, E.: Cytotoxic T cell response to H-Y: correlation with the rejection of syngeneic male skin grafts.J Exp Med 147: 768–775, 1978

    PubMed  Google Scholar 

  • Koizumi, A., Walford, R. L., and Hasegawa, L.: Differences in H-2 recombinant mice in the 0-naphtoflavone inducibility of the mixed function monooxygenase, P,-450.Immunogenetics 26: 169–173, 1987

    PubMed  Google Scholar 

  • Lilly, F., Boyse, E. A., and Old, L. J.: Genetic basis of susceptibility to viral leukemogenesis.Lancet 2: 1207–1209, 1964

    Google Scholar 

  • Mantel, N.: Evaluation of survival data and two new rank order statistics arising and its consideration.Cancer Chemother Rep 50: 163–170, 1966

    PubMed  Google Scholar 

  • McKenzie, I. F. C., Morgan, G. M., Melvold, R. W., and Kohn, H. L: BALB/c-H-2db: a new H-2 mutant in BALB/cKh that identifies a locus associated with the D region.Immunogenetics 4.: 333–347, 1977

    Google Scholar 

  • Miyashita, N. and Moriwaki, K.: H-2-controlled genetic susceptibility to pulmonary adenomas induced by urethane and 4-nitroquinoline 1-oxide in A/Wy congenic strains.Jpn J Cancer Res 78: 494–498, 1987

    PubMed  Google Scholar 

  • Mühlbock, O. and Dux, A.: Histocompatibility genes and mammary cancer. In J. Hilgers, M. Sluyser (eds.):Mammary Tumors in the Mouse, pp. 545-572, Elsevier/North Holland, Amsterdam, 1981

    Google Scholar 

  • Oomen, L. C. J. M., Demant, P., Hart, A. A. M., and Emmelot, P.: Multiple genes in the H-2 complex affect differently the number and growth rate of transplacentally induced lung tumors in mice.Int J Cancer 31: 447–454, 1983

    PubMed  Google Scholar 

  • Oomen, L. C. J. M., van der Valk, M. A., Demant, P., and Emmelot, P.: The mouse major histocompatibility complex (H-2) influence on N-ethyl-N-nitrosourea-induced tumor formation in various organs.Cancer Res 48: 6634–6641, 1988

    PubMed  Google Scholar 

  • Oomen, L. C. J. M., van der Valk, M. A., Hart, A. A. M., and Demant, P.: Glucocorticoid hormone effect on transplacental carcinogenesis and lung differentiation: influence of Histocompatibility-2 complex.J Natl Cancer Inst 81: 512–517, 1989

    PubMed  Google Scholar 

  • Palumbo, D. A. and Vladutiu, A. O.: Estrogen receptor in uteri of mice of different H-2 genotypes.Experientia 35: 1103–1104, 1979

    PubMed  Google Scholar 

  • RÖpcke, G., Sluyser, M., and Demant, P.: The H-2 complex and the hormonal factors in mammary tumorigenesis in mice. In C. S. David (ed.):H-2 Antigens: Genes, Molecules, and Functions, pp. 681–689, Plenum, New York, 1987

    Google Scholar 

  • Sluyser, M., Boot, L. M., and Röpcke, G.: High estrogen and low progestin receptor levels in outgrowths of hypophyseal isografts.Cancer Res 38: 2859–2860, 1978

    PubMed  Google Scholar 

  • Snoek, M. and Demant, P.: Analysis of the expression of H-2 and H-2-linked antigens on mammary tumor cells.Int J Cancer 24: 165–167, 1979

    PubMed  Google Scholar 

  • van der Gugten, A. A., Röpcke, G., van Nie, R., and Hilgers, J.: Mouse strain (STS/A) resistant to mammary tumor induction by hypophyseal isografts.Cancer Res 45: 3448–3453, 1985

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Röpcke, G., Moen, C.J.A., Hart, A.A.M. et al. Effects of the MHC on hormonal induction of mammary tumors and function of hypophyseal isografts in the mouse. Immunogenetics 31, 347–355 (1990). https://doi.org/10.1007/BF02115009

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02115009

Keywords

Navigation