Skip to main content
Log in

Meiotic recombination at the Lmp2 hotspot tolerates minor sequence divergence between homologous chromosomes

  • Brief Communications
  • Published:
Immunogenetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Committee for Mouse Chromosome 17. Maps of mouse chromosome 17: First report. Mammalian Genome 1: 5–29, 1991

    Google Scholar 

  • Gotoh, H., Kusakabe, M., Shiroishi, T., and Moriwaki, K. Survival of steroid 21-hydroxylase-deficient mice without endogenous corticosteroids after neonatal treatment and genetic rescue by transgenesis as a model system for treatment of congenital adrenal hyperplasia in humans. Endocrinology 135: 1470–1476, 1994

    Google Scholar 

  • Jacob, C. O. and Hwang, F. Definition of microsatellite size variants for Tnfa and Hsp70 in autoimmune and nonautoimmune mouse strains. Immunogenetics 36: 182–188, 1992

    Google Scholar 

  • Lafuse, W. P., Lee, S. T., Castle, L., and David, C. S. Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between and C4 genes. Immunogenetics 30: 387–389, 1989

    Google Scholar 

  • Riele, H. T., Maandag, E. R., and Berns, A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA construct. Proc Natl Acad Sci USA 89: 5128–5132, 1992

    Google Scholar 

  • Robinson, R. R., Germain, R. N., McKean, D. J., Mescher, M., and Seidman, J. G. Extensive polymorphism surrounding the murine la Ab chain gene. J Immunol 131: 2025–2031, 1983

    Google Scholar 

  • Saha, B. K., Shields, J. J., Miller, R. D., Hansen, T. H., and Shreffler, D. C. A highly polymorphic microsatellite in the class II Eb gene allows tracing of major histocompatibility complex evolution in mouse. Proc Natl Acad Sci USA 90: 5312–5316, 1993

    Google Scholar 

  • Shen, P. and Huang, H. V. Effect of base pair mismatches on recombination via the RecBCD pathway. Mol Gen Genet 218: 358–360, 1989

    Google Scholar 

  • Shiroishi, T., Sagai, T., and Moriwaki, K. A new wild-derived H-2 haplotype enhancing K-IA recombination. Nature 300: 370–372, 1982

    Google Scholar 

  • Shiroishi, T., Sagai, T., Natsuume-Sakai, S., and Moriwaki, K. Lethal deletion of the complement C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by meiotic recombination. Proc Natl Acad Sci USA 84: 2819–2823, 1987

    Google Scholar 

  • Shiroishi, T., Hanzawa, N., Sagai, T., Ishiura, M., Gojobori, T., Steinmetz, M., and Moriwaki, K. Recombinational hotspot specific to female meiosis in the mouse major histocompatibility complex. Immunogenetics 31: 79–88, 1990

    Google Scholar 

  • Shiroishi, T., Sagai, T., Hanzawa, N., Gotoh, H., and Moriwaki, K. Genetic control of sex-dependent meiotic recombination in the major histocompatibility complex of the mouse. EMBO J 10: 681–686, 1991

    Google Scholar 

  • Shiroishi, T., Sagai, T., and Moriwaki, K. Hotspots of meiotic recombination in the mouse major histocompatibility complex. Genetica 88: 187–196, 1993

    Google Scholar 

  • Shiroishi, T., Koide, T., Yoshino, M., Sagai, T., and Moriwaki, K. Hotspots of homologous recombination in mouse meiosis. Adv Biophys 31: 119–132, 1995

    Google Scholar 

  • Steinmetz, M., Minard, K., Horvath, S., McNicholas, J., Srelinger, J., Wake, C., Long, E., Mach, B., and Hood, L. A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300: 35–42, 1982

    Google Scholar 

  • Waldman, A. S. and Liskay, R. M. Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology. Mol Cell Biol 8: 5350–5357, 1988

    Google Scholar 

  • White, M. A., Detloff, P., Strand, M., and Petes, T. D. A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast. Curr Genet 21: 109–116, 1992

    CAS  PubMed  Google Scholar 

  • Yoshino, M., Sagai, T., Fischer Lindahl, K., Toyoda, Y., Shiroishi, T. and Moriwaki, K. No dosage effect of recombinational hotspots inthe mouse major histocompatibility complex. Immunogenetics 39: 381–389, 1994a

    Google Scholar 

  • Yoshino, M., Sagai, T., Fischer Lindahl, K., Toyoda, Y., Shirayoshi, Y., Matsumoto, K., Sugaya, K., Ikemura, T., Moriwaki, K., and Shiroishi, T. Recombination in the class III region of the mouse major histocompatibility complex. Immunogenetics 40: 280–286, 1994b

    Google Scholar 

  • Yoshino, M., Sagai, T., Fischer Lindahl, K., Toyoda, Y., Moriwaki, K., and Shiroishi, T. Allele-dependent recombination frequency: homology requirement in meiotic recombination at the hotspot in the mouse major histocompatibility complex. Genomics 27: 298–305, 1995

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yoshino, M., Sagai, T., Moriwaki, K. et al. Meiotic recombination at the Lmp2 hotspot tolerates minor sequence divergence between homologous chromosomes. Immunogenetics 43, 80–82 (1995). https://doi.org/10.1007/BF00186609

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00186609

Keywords

Navigation