Abstract
Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.
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Correspondence to: R. B. Lingham
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Lingham, R.B., Silverman, K.C., Bills, G.F. et al. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protien transferase. Appl Microbiol Biotechnol 40, 370–374 (1993). https://doi.org/10.1007/BF00170395
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DOI: https://doi.org/10.1007/BF00170395