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Mixed-sclerosing-bone-dystrophy: Report of a case and review of the literature

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Abstract

We present clinical, laboratory, radiologic, genetic, and pathologic findings in a 49-year-old man with mixed-sclerosing-bone-dystrophy (MSBD), review the six cases previously reported as “MSBD”, and examine the nosology of this rare bone dysplasia. Our asymptomatic patient showed radiographic changes consistent with osteopoikilosis, osteopathia striata, and melorheostosis and had widespread osteosclerosis of the axial skeleton. Several previous reports of combined osteosclerotic disorders suggest the latter finding represents osteopetrosis, however, histologic examination of our patient's iliac crest excluded that diagnosis. Limited radiographic surveys of his eight children were unremarkable except for isolated bone islands in two sons. Literature review revealed that “MSBD” has actually been used generically to describe the association of a variety of osteosclerotic bone dysplasias when they occur together in a single patient.

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Authors and Affiliations

  1. Division of Bone and Mineral Metabolism, Department of Medicine, The Jewish Hospital of St. Louis; Washington University School of Medicine, St. Louis, Missouri, USA

    Michael P. Whyte M.D. & Theodore J. Hahn M.D.

  2. The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

    William A. Murphy M.D.

  3. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis; Washington University School of Medicine, St. Louis, Missouri, USA

    Michael D. Fallon M.D.

Authors
  1. Michael P. Whyte M.D.
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  2. William A. Murphy M.D.
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  3. Michael D. Fallon M.D.
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  4. Theodore J. Hahn M.D.
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Whyte, M.P., Murphy, W.A., Fallon, M.D. et al. Mixed-sclerosing-bone-dystrophy: Report of a case and review of the literature. Skeletal Radiol. 6, 95–102 (1981). https://doi.org/10.1007/BF00347570

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