Abstract
Immediately after coronarography 10 mCi 133Xenon were injected into the left or right coronary artery. A scintillation camera was placed above the thorax of the patient. A computer unit (KRUPP EPR 2500) with magnetic tapes and discs is available for data processing and data storage. Sequential images of the heart are taken over a period of 2 min in a two-second-frame mode and stored on magnetic tape. The total image was divided into 5·5 mm areas. From each area a functional curve was registered and the Myocardial Blood Flow (ml/min/100 g myocard) could be calculated from that. For a precise evaluation of the image of the Myocardial Blood Flow, any influences originating from other regions of the body had to be excluded. Therefore all curves are rejected which did not (a) reach their maximum value within 15s after injection, or (b) where the maximum was less than 10% of the highest maximum value of the reference curve. The values of the Myocardial Blood Flow calculated in this manner are displayed on a TV-screen. These values can be transformed into 10 colors or grey levels.
This method has been proven to be useful in clinical practice for functional studies, especially for the judgement of the effectivity of pharmaceuticals. The quantitative display technique of the ‘Myocardial Blood Flow” improves the clinical statement in comparison to a scintigraphic picture.
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Bonte, F. J., Parkey, R. W., Stokely, E. M., Lewis, S. E., Horwitz, L. D., Curry, G. C.: Radionuclide determination of myocardial blood flow. Seminars in Nuclear Med. 3, No. 2, 153–163 (1973)
Conn, H. L., Jr.: Equilibrium distributation of radioxenon in tissue: xenon-hemoglobin association curve. J. appl. Physiol. 16, 1065 (1961)
Engel, H.-J., Heim, R., Liese, W., Hundeshagen, H., Lichtlen, P.: Regional myocardial perfusion at rest in coronary disease assessed by microsphere scintigraphy and inert gas clearance. 25th session American College of Cardiology, New Orleans, Februar 1976
Hundeshagen, H.: Die digitale Radionuklid-Angiokardiographie. 12. Jahrestagung d. Ges. f. Nuklearmedizin München, September 1974
Hundeshagen, H., Jordan, K., Sippel, R., Nentwig, C., Gettner, U., Geisler, S.: Der Einsatz einer Prozeßrechner-gesteuerten Szintillationskamera zur phasengerechten Funktionsszintigraphie des Herzens im Vergleich zu Radiokardiographie. Tagung der Ges. f. Nuklearmedizin, Freiburg 1972
Hundeshagen, H., Lichtlen, P., Liese, W., Sippel, R.: Überprüfung eines Beurteilungsschemas der Myokard-Perfusions-Szintigraphie durch die vergleichende Koronarographie. 12. Jahrestagung d. Ges. f. Nuklearmedizin München, September 1974
Kety, S. S., Schmidt, C. F.: the determination of cerebral blood flow in man by use of nitrous oxide in low concentrations. Amer. J. Physiol. 144, 53 (1945)
Lichtlen, P., Engel, H.-J., Hundeshagen, H.: Regional myocardial blood flow in patients without coronary artery disease, yet proven myocardial infarctions. 25th session of the American College of Cardiology, New Orleans, Februar 1976
Lichtlen, P., Gattiker, K., Scholer, Y., Schibli, R.: Koronarfluß unter Arbeit bei Koronarsklerose, gemessen anhand der präkordialen Xenon-Clearance-Technik. Verh. dtsch. Ges. Kreisl.-Forsch. 39, 301–304 (1973)
Lichtlen, P., Halter, J., Gattiker, K.: The effect of isosorbiddinitrate on coronary blood flow, coronary resistance and left ventricular dynamics under exercise in patients with coronary artery disease. Basis Res. in Cardiol. 69, No. 4, 402–421 (1974)
Lichtlen, P., Moccetti, T., Halter, J.: The importance of perfusion pressure, left ventricular work and oxygen consumption in determining myocardial blood flow in man, especially in coronary patients. Cardiology 56, 347–353 (1971/72)
Lichtlen, P., Moccetti, T., Halter, J., Schönbeck, M., Senning, A.: Postoperative evaluation of myocardial blood flow in aorta-tocoronary artery vein bypass grafts using the xenon-residue detection technic. Circulation 46, 445–455 (1972)
Liese, W., Engel, H.-J., Heim, R., Hundeshagen, H., Lichtlen, P., Rafflenbeul, W.: Diagnostische Wertigkeit der Perfusionsszintigraphie des Myokards bei Koronarsklerose. Schweiz med. Wschr. 105, 1474–1476 (1975)
Nentwig, C., Jordan, K.: Verbesserung des zeitlichen Auflösungsvermögens einer Gammakamera. In: H. W. Pabst, Nuklearmedizin. S. 309. Stuttgart: Schattauer 1973
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Hundeshagen, H., Geisler, S., Dittmann, P. et al. Quantitative scintigraphic display of myocardial blood flow. Eur J Nucl Med 1, 107–115 (1976). https://doi.org/10.1007/BF00263052
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DOI: https://doi.org/10.1007/BF00263052