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Preparation and evaluation of 99mTc(V)-DMSA complex: Studies in medullary carcinoma of thyroid

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Abstract

Consequent to the promising results reported with 99mTc(V)-DMSA for imaging certain types of soft tissue tumors, we have developed methods to prepare this radiopharmaceutical in three ways:-(i) from freshly prepared reagents, (ii) through the use of a two component kit and (iii) use of the standard renal DMSA kit by a modified recipe. The 99mTc(V)-DMSA complex has been subjected to paper electrophoretic and chromatographic procedures and also biodistribution studies. The distinctly different behaviour of this new product compared to that of the well known renal DMSA complex has been clearly established. Scintiimaging in a preliminary clinical trial in patients with medullary carcinoma of the thyroid has been encouraging.

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Authors and Affiliations

  1. ISOPHARM, Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Turbhe Complex, 400 705, New Bombay, India

    N. Ramamoorthy, Smita V. Shetye, Prakash M. Pandey & R. S. Mani

  2. Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, 400 012, Bombay, India

    M. C. Patel, R. B. Patel, P. Ramanathan, B. A. Krishna & S. M. Sharma

Authors
  1. N. Ramamoorthy
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  2. Smita V. Shetye
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  3. Prakash M. Pandey
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  4. R. S. Mani
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  5. M. C. Patel
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  6. R. B. Patel
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  7. P. Ramanathan
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  8. B. A. Krishna
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  9. S. M. Sharma
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Ramamoorthy, N., Shetye, S.V., Pandey, P.M. et al. Preparation and evaluation of 99mTc(V)-DMSA complex: Studies in medullary carcinoma of thyroid. Eur J Nucl Med 12, 623–628 (1987). https://doi.org/10.1007/BF00284540

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  • DOI: https://doi.org/10.1007/BF00284540

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