Abstract
Positron emission tomography with 11C-palmitate and single photon imaging with terminally radioiodinated fatty acid analogues (123I-FFA) were evaluated for the non-invasive assessment of regional myocardial fatty acid metabolism during ischaemia. Decreased uptake of tracer and delayed clearance of activity in the ischaemic myocardium were reported for both 11C-and 123I-labelled compounds. However, since during ischaemia both myocardial blood flow and oxidative metabolism are reduced concomitantly, either factor can be responsible for the changes observed. Experimental preparations in which fatty acid metabolism can be modified independently of flow are helpful for the characterization of the relationship between metabolism and myocardial kinetics of labelled fatty acids. Results obtained during flow-independent inhibition of fatty acid oxidation include the following observations:
-
- In dogs with controlled coronary perfusion the rate of clearance of 11 C-palmitate activity is decreased during diminished delivery of oxygen, regardless of whether myocardial perfusion is concomitantly reduced or not.
-
- In isolated rabbit hearts perfused at normal flow, the extraction of 123 I-FFA is decreased during hypoxia.
-
- During pharmacological inhibition of fatty acid oxidation the deiodination of 123 I_FFA is markedly reduced in rat hearts in vivo and in vitro.
Similar content being viewed by others
References
Bergmann SR, Clark RE, Sobel BE (1979) An improved isolated heart preparation for external assessment of myocardial metabolism. Am J Physiol 236: H644-H651
Chatelain P, Lüthy P, Büsslinger B, Moret P, Blauenstein P, Lerch R (1984) Effect of reduced fatty acid metabolism on myocardial I-123 release from I-123-heptadecanoic acid. J Mol Cell Cardiol 16 [Suppl 2]:72 (abstract)
Fox KAA, Abendschein D, Ambos HD, Sobel BE, Bergmann SR (1985) Backdiffusion of labeled fatty acid from canine myocardium: implications for quantifying myocardial metabolism tomographically. Circ Res 57:232–243
Kloster G, Stöcklin G, Smith III EF, Schrör K (1984) ω-halofatty acids: a probe for mitochondrial membrane integrity Eur J Nucl Med 9:305–311
Lerch RA, Ambos HD, Bergmann SR, Welch MJ, Ter-Pogossian MM, Sobel BE (1981) Localization of viable, ischemic myocardium by positron-emission tomography with 11C-palmitate. Circulation 64:689–699
Lerch RA, Bergmann SR, Ambos HD, Welch MJ, Ter-Pogossian MM, Sobel BE (1982) Effect of flow-independent reduction of metabolism on regional myocardial clearance of 11C-palmitate. Circulation 65:731–738
Lerch R, Fleisch M, Büsslinger B, Ratib O, Rutishauser W (1984) L'effet de l'inhibition du métabolisme des acides gras sur l'extraction myocardique de I-123-heptadécanoate. Schweiz Med Wochenschr 114:1618–1619 (abstract)
Liedtke AJ (1981) Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 23:321–336
Machulla HJ, Stöcklin G, Kupfernagel C, Freundlieb C, Höck A, Vyska K, Feinendegen LE (1978) Comparative evaluation of fatty acids labeled with C-11, Cl-34m Br-77, and I-123 for metabolic studies of the myocardium: Concise communication. J Nucl Med 19:298–302
Okada RD, Elmaleh D, Werre GS, Strauss HW (1983) Myocardial kinetics of 123I-labeled-16-hexadecanoic acid. Eur J Nucl Med 8:211–217
Schelbert HR, Henze E, Keen R, Schön HR, Hansen H, Selin C, Huang SC, Barrio JR, Phelps ME (1983) C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. IV. In vivo evaluation of acute demand-induced ischemia in dogs. Am Heart J 106:736–750
Schön HR, Schelbert HR, Najafi A, Hansen H, Huang H, Barrio J, Phelps ME (1982) C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography. II. Kinetics of C-11 palmitic acid in acutely ischemic myocardium. Am Heart J 103:548–561
Van der Wall EE, Westera G, den Hollander W, Visser FC (1981) External detection of regional myocardial metabolism with radioiodinated hexadecenoic acid in the dog heart. Eur J Nucl Med 6:147–151
Weiss ES, Hoffman EJ, Phelps ME, Welch MJ, Henry PD, TerPogossian MM, Sobel BE (1976) External detection and visualization of myocardial ischemia with 11C-substrates in vivo and in vitro. Circ Res 39:24–32
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lerch, R. Effect of impaired fatty acid oxidation on myocardial kinetics of 11C-and 123I-labelled fatty acids. Eur J Nucl Med 12 (Suppl 1), S36–S38 (1986). https://doi.org/10.1007/BF00258102
Issue Date:
DOI: https://doi.org/10.1007/BF00258102