Abstract
Hexakis (methoxyisobutilisonitrile) technetium(I), 99mTc-MIBI, has been proposed for myocardial perfusion studies. We have evaluated the biodistribution of this new agent in normal volunteers at rest and after stress. The biodistribution of 99mTc-MIBI is characterized by rapid blood clearance and a consequently early myocardial uptake. The initial intense hepatic activity is cleared into the gallbladder at 1 h after injection, and the best target to non target ratio is observed at 60–90 min after injection. Absorbed radiation dose calculations show that the thyroid is the critical target organ (230 mRad/mCi at rest), presumably because of 99mTc-pertechnetate generated in vivo. Our results indicate that 99mTc-MIBI is a promising tracer for myocardial perfusion imaging.
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References
Dean RT, Adams MD (1984) Myocardial kinetics of hexakis-(trimethylphosphite)technetium-99m(I) chloride (Tc-TMP) in rats, rabbits, dogs, cats and pigs. J Nucl Med 25:15
Deutsch E, Buseman Sokole E, Samson G, Schoot Van Der JB, Lie KI, Wellens HJJ (1977) Value and limitation of Thallium-201 scintigraphy in the acute phase of myocardial infarction. N Engl J Med 295:1–5
Deutsch E, Glavan KA, Sodd VJ, Nishiyama H, Ferguson DL, Lukes SJ (1981) Cationic 99mTc complexes as potential myocardial imaging agents. J Nucl Med 22:897–907
Ferrant A, Cauwe F (1979) Quantitative organ uptake measurement with a gamma camera. Eur J Nucl Med 4:223–229
Gerson MC, Deutsch E, Nishiyama H, Libson K, Adolph RJ, Grossman LW, Sodd VJ, Fortman DL, Vanderheyeden JL, Williams JJ, Saenger EL (1983) Myocardial perfusion imaging with Tc-99m-DMPE in man. Eur J Nucl Med 8:371–374
Gerundini P, Deutsch E, Savi A, Gilardi MC, Zecca L, Hirth W, Libson K, Fazio F (1985) Three new Tc-99m complexes as myocardium perfusion tracers. Eur J Nucl Med 11:A39 (abstr.)
Gerundini P, Savi A, Gilardi MC, Margonato A, Vicedomini G, Zecca L, Hirth W, Libson K, Bhatia JC, Fazio F (1986) Evaluation in dogs and humans of three potential technetium-99m myocardial perfusion agents. J Nucl Med 27:409–416
Holman BL, Jones AG, Lister-James J, Davison A, Abram MJ, Kirshenbaum JM, Tumeh SS, English RJ (1984) A new 99mTc labeled myocardial imaging agent, hexakis(t-butylisonistrile)-technetium(I) Tc-99m TBI: initial experience in the human. J Nucl Med 25:1350–1355
Holman BL, Sporn V, Jones AL, Sia STB, Perez-Balino N, Davison A, Lister-James J, Kronague JF, Mitta AEA, Camin LL, Campbell S, Williams SJ, Carpenter AT (1987) Myocardial imaging with Technetium-99m CPI: initial experience in the human. J Nucl Med 28:13–18
Kronague JF, Jones AG, Davidson A, Lister-James J, Williams SJ, Mousa SA (1986) Isonitrile ester complexes of Technetium. J Nucl Med 27:894
Liu P, Mills L, Lamb AC, Houle S, Allidina Y, Lewis M (1987) Imaging of coronary occulusion and reperfusion with Tc-99m Methoxy butyl Isonitrile (Tc-99m-MIBI): comparison with microspheres. J Nucl Med 28:620
McKusik K, Holman BL, Jones AG, Rijo P, Sporn V, Vosberg H, Moretti J (1986) Comparison of three Tc-99m isonitriles for detection ischemic heart disease. J Nucl Med 27:878
MN/MIRD Pamphlet n. 11 (1975) Society of Nuclear Medicine, New York
Mousa SA, Maina M, Brown BA, Williams SJ (1987a) Retention of RP-30 in the heart may be due to binding to a cytosolic protein. J Nucl Med 28:619
Mousa SA, Loaney JM, Williams SJ (1987b) Regional myocardial distribution of RP-30 in animal models of myocardial ischemia and reperfusion. J Nucl Med 28:626
Myres MJ, Lavander JP, De Oliveira JB, Maseri A (1981) A simplified method of quantitating organ uptake using a gamma camera. British J Radiology 54:1062–1067
Rigo P, Larock MP, Cantineau R (1987) Evaluation of extent of coronary artery disease with Tc99m-MIBI, a new myocardial perfusion agent. J Nucl Med 28:655
Thakur ML, Park CM, Fazio F, Gerundini P, Margonato A, Vicedomini G, Colombo F, Gilardi MC, Fregoso A, Bencivelli W, Taddei G (1984) Preparation and evaluation of (99mTc)DEPE as a cardiac perfusion agent. Int J Appl Radiat Isot 34:507–515
Webster DW, Nosco DL, Coveney JR, Dean RT, Gerundini P, Zecca L, Savi A, Fazio F (1986) New Tc-99m myocardial agents with low plasma binding and fast blood clearance. J Nucl Med 27:894
Williams SJ, Mousa SA, Morgan RA, Carrol TR, Maheu LJ (1986) Pharmacology of Tc-99m isonitriles: agents with favorable characteristics for heart imaging. J Nucl Med 27:877–878
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Savi, A., Gerundini, P., Zoli, P. et al. Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans. Eur J Nucl Med 15, 597–600 (1989). https://doi.org/10.1007/BF00256936
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DOI: https://doi.org/10.1007/BF00256936