Abstract
Samples of fresh thyroid tissue obtained from 15 patients undergoing thyroid surgery were incubated with iodine 125 in culture solution to which thyroid-stimulating hormone (TSH) had been added and then examined by autoradiography. The radioactivity registered actively during the 90-min incubation period was primarily found in the lumina of follicles. Even morphologically similar follicles showed very heterogeneous uptake of radioiodine; small follicles often contained the highest concentrations of activity. The method applied appears to be particularly useful for answering the question as to whether and to what extent individual papillary or follicular thyroid carcinomas are able to store radioiodine. This information obtained immediately after surgery may contribute towards establishing the patient's prognosis and help in deciding on postoperative therapy and follow-up. Because of the heterogeneity of radioiodine uptake, it is mandatory to examine a representative sample of carcinoma tissue in order to obtain well-established results.
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References
Beierwaltes WH, Nishiyama RH, Thompson NW, Copp JE, Kubo A (1982) Survival time and “cure” in papillary and follicular thyroid carcinoma with distant metastases: statistics following University of Michigan therapy. J Nucl Med 23:561–568
Chambard M, Verrier B, Gabrion J, Mauchamp J, Bugeia JC, Pelassy C, Mercier B (1983) Polarization of thyroid cells in culture: evidence for the basolateral localization of the iodide “pump” and of the thyroid-stimulating hormone receptoradenyl cyclase complex. J Cell Biol 96:1172–1177
Dobyns BM, Lennon B (1948) A study of the histopathology and physiologic function of thyroid tumors, using radioactive iodine and radioautography. J Clin Endocrinol Metab 8:732–748
Edmonds CJ, Kermode JC (1985) Thyrotrophin receptors, tumor radioiodine concentration and thyroglobulin secretion in differentiated thyroid cancer. Br J Cancer 52:537–541
Edmonds CJ, Hayes S, Kermode JC, Thompson BD (1977) Measurement of serum TSH and thyroid hormones in the management of treatment of thyroid carcinoma with radioiodine. Br J Radiol 50:799–807
Ekholm R, Wollman SH (1975) Site of iodine in the rat thyroid gland deduced from electron microscopic autoradiographs. Endocrinology 97:1432–1444
Ekholm R, Engstrbm G, Ericson LE, Melander A (1975) Exocytosis of protein into the thyroid follicle lumen: an early effect of TSH. Endocrinology 97:337–346
Fitzgerald PJ (1948) Histologic types of thyroid carcinoma and their respective abilities to store radioactive iodine131 as demonstrated by radioautograms. In: Radiology. Brookhaven Conference Report BNL-C-5. Brookhaven National Laboratory, Associated Universities, Upton, NY, pp 91–94
Fitzgerald PJ, Foote FW (1949) The function of various types of thyroid carcinoma as revealed by the radioautographic demonstration of radioactive iodine131 (I131). J Clin Endocrinol 9:1153–1170
Fitzgerald PJ, Foote FW, Hill RF (1950) Concentration of I131 in thyroid cancer, shown by radioautography. Cancer 3:86–105
Frantz VK, Quimby EH, Evans TC (1948) Radioactive iodine studies of functional thyroid carcinoma. Radiology 51:532–552
Jänsch A, Heinze HG, Hast B (1981) Serum-Thyreoglobulin (ShTG): ein Tumormarker bei Patienten mit differenziertem Schilddrüsenkarzinom. Strahlentherapie 157:381–392
Keston AS, Ball RP, Frantz VK, Palmer WW (1942) Storage of radioactive iodine131 in a metastasis from thyroid carcinoma. Science 95:362–363
Marinelli LD, Foote FW, Hill RF, Hocker AF (1947) Retention of radioactive iodine131 in thyroid carcinomas; histopathologic and radioautographic studies. Am J Roentgenol 58:17–32
Seidlin SM, Marinelli LD, Oshry E (1946) Radioactive iodine131 therapy; effect on functioning metastases of adenocarcinoma of the thyroid. JAMA 132:838–847
Thomas-Morvan C, Carayon P, Schlumberger M, Vignal A, Tubiana M (1982) Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer. Acta Endocrinol 101:25–31
Wollman SH, Wodinsky I (1955) Localization of protein-bound I131 in the thyroid gland of the mouse. Endocrinology 56:9–20
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Ahuja, S., Schiller, S. & Ernst, H. An autoradiography study of postoperatively labelled thyroid tissue and iodine storage. Eur J Nucl Med 18, 791–795 (1991). https://doi.org/10.1007/BF00175056
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DOI: https://doi.org/10.1007/BF00175056