Abstract
The first commercial version of the Massachusetts General Hospital (MGH) positron camera was used to image the relative distributions of 13N (T 1/2=9.96min) in the human heart, pancreas, and liver after intravenous administration of [13N]-l-glutamate. The instrument was operated in two imaging modes. Conventional 2-dimensional (2-D) focal-plane images showed high concentrations of 13N in the heart and pancreas, and lower levels in the liver. Five PET tomographic transverse section (3-D) images were made through the heart and three through the pancreas. Our results suggest that further studies designed to gain an improved understanding of the biochemistry of [13N]-l-glutamate aided by PET imaging, especially with newer instrumentation, are worthy of further investigation.
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References
Brownell GL, Correia JA, Zamenhof RG (1978) Positron instrumentation. In: Lawrence JH, Budinger TF (eds) Recent advances in nuclear medicine, vol 5, Grune & Stratton, New York, 1–49
Buonocure E, Hübner KF (1979) Positron-emission computed tomography of the pancreas: A preliminary study. Radiology 133:195–201
Carroll LR (1978) Design and performance characteristics of a production model positron imaging system. IEEE Trans Nucl Sci NS-25:606–614
Chesler DA (1971) Three-dimensional activity distribution from multiple positron scintigraphs. J Nucl Med 12:347–348 (Abstr)
Cho ZH, Cohen MB, Singh M, Eriksson L, Chan J, Macdonald N, Spolter L (1977) Performance and evaluation of the circular ring transverse axial positron camera (CRTAPC). In: Medical radionuclide imaging, vol 1, IAEA, Vienna, 269–290
Cooper AJL, Gelbard AS (1981) The use of immobilized glutamate dehydrogenase to synthesize 13N-labeled L-amino acids. Anal Biochem 111:42–48
Gelbard AS, Benua RS, Reiman RE, McDonald JM, Vomero JJ, Laughlin JS (1980) Imaging of the human heart after administration of l-(N-13) glutamate. J Nucl Med 21:988–991
Henze E, Schelbert HR, Barrio JR, Egbert JE, Hansen HW, Mac-Donald NS, Phelps ME (1982) Evaluation of myocardial metabolism, with N-13- and C-11-labeled amino acids and positron computed tomography. J Nucl Med 23:671–681
Knapp WH, Helus F, Ostertag H, Tillmanns H, Kübler W (1982) Uptake and turnover of l-(13N)-glutamate in normal human heart and in patients with coronary artery disease. Eur J Nucl Med 7:211–215
Lathrop KA, Harper PV, Rich BH, Dinwoodie, R, Krizek H, Lembares N, Gloria I (1973) Rapid incorporation of short-lived cyclotron-produced radionuclides into radiopharmaceuticals. In: Radiopharmaceuticals and labelled compounds, Vol I. IAEA, Vienna, 471–481
Laughlin JS, Ritter FW, Dwyer AJ, Mayer K, Greenberg EJ, Dimich AB, Hasan S, Rothschild E, Myers WPL (1970) Development and applications of quantitative and computer-analyzed counting and scanning. Cancer 25:395–405
Laughlin JS (1971) The cyclotron in nuclear medicine. In: Blahd WH (ed) Nuclear medicine. 2nd ed McGraw-Hill, New York, 677–692
Mudge GH Jr, Mills RM Jr, Taegtmeyer H, Gorlin R, Lesch M (1976) Alterations of myocardial amino acid metabolism in chronic ischemic heart disase. J Clin Invest 58:1185–1192
Myers WG (1980) PET=Positron+Electron Transmutation. J Nucl Med 21:1200 (Letter to the editor)
Rau EE, Shine KI, Gervais A, Douglas AM, Amos III EC (1979) Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion. Am J Physiol 5:H873-H879
Sanborn T, Gavin W, Berkowitz S, Perille T, Lesch M (1979) Augmented conversion of aspartate and glutamate to succinate during anoxia in rabbit heart. Am J Physiol 6:H535-H541
Schelbert HR, Henze E, Phelps ME (1980) Emission tomography of the heart. Semin Nucl Med 10:355–373
Syrota A, Comar D, Cerf M, Plummer D, Maziere M, Kellershohn C (1979) [11C]Methionine pancreatic scanning with positron emission computed tomography. J Nucl Med 20:778–781
Taegtmeyer H, Ferguson AG, Lesch M (1977) Protein degradation and amino acid metabolism in autolyzing rabbit myocardium. Exp Mol Pathol 26:52–62
Vogel RA (1980) Quantitative aspects of myocardial perfusion imaging. Semin Nucl Med 10:146–156
White A, Handler P, Smith EL, Hill RL, Lehman IR (1978) Principles of biochemistry. 6th ed McGraw-Hill, New York, 358, 665–660, 1101, 1267
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Myers, W.G., Bigler, R.E., Benua, R.S. et al. PET tomographic imaging of the human heart, pancreas, and liver with nitrogen-13 derived from [13N]-L-glutamate. Eur J Nucl Med 8, 381–384 (1983). https://doi.org/10.1007/BF00253210
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DOI: https://doi.org/10.1007/BF00253210