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Natural resistance against hematopoietic cells in lethally-irradiated mice infected with Friend leukemia virus

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Summary

The influence of in vivo infection with the polycythemic substrain of Friend leukemia virus on noninducible (‘natural’) resistance against allogeneic normal or malignant grafts was studied in lethally irradiated mice. Parallel studies were performed on the NK system in the same experimental conditions. The results indicate that FLV-P infection of mice with full (DBA/2) vs partial (BALB/c and CD2F1) susceptibility did not suppress their in vivo natural resistance against bone marrow or El-4 leukemia cells. On the other hand, a decline in NK activity paralleled the progression of leukemic disease in the more susceptible DBA/2 hosts.

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References

  1. Bennett M (1972) Rejection of marrow allograft. Transplantation 14:288

    Google Scholar 

  2. Bonmassar E, Cudkowicz G (1976) Suppression of allogeneic lymphomas in spleens of irradiated mice: importance of the D end of the H-2 complex. J Immunol 117:697

    Google Scholar 

  3. Bonmassar E, Campanile F, Houchens D, Crinò L, Goldin A (1975) Impaired growth of a radiation-induced lymphoma in intact or lethally irradiated allogeneic athymic (nude) mice. Transplantation 20:343

    Google Scholar 

  4. Bonmassar E, Riccardi C, Campanile F, Iorio A, Puccetti P, Herberman RB (1979) Radioresistant inhibition of tumors (RIT): biological and pharmacological studies. In: Ferrone S, Herberman RB, Gorini S, Reisfeld RA (eds) Current trends in tumor immunology. Garland, New York London, p 49

    Google Scholar 

  5. Bonmassar A, Riccardi C, Rivosecchi-Merletti P, Goldin A, Bonmassar E (1980) Transplantation resistance of drug-treated hybrid or allogeneic mice against murine lymphomas. I. Immunopharmacology studies. Int J Cancer 26:819

    Google Scholar 

  6. Campanile F, Crinò L, Bonmassar E, Houchens D, Goldin A (1977) Radioresistant inhibition of lymphoma growth in congenitally athymic (nude) mice. Cancer Res 37:394

    Google Scholar 

  7. Cikes M, Friberg S Jr, Klein G (1973) Progressive loss of H-2 antigens with concomitant increase of cell-surface antigen(s) determined by Moloney leukemia virus in cultured lymphomas. J Natl Cancer Inst 50:347

    Google Scholar 

  8. Clark EA, Harmon RC (1980) Genetic control of natural cytotoxicity and hybrid resistance. Adv Cancer Res 31:227

    Google Scholar 

  9. Cudkowicz G (1968) Hybrid resistance to parental grafts of hematopoietic and lymphoma cells. In: The proliferation and spread of neoplastic cells Williams and Wilkins, Baltimore, p 661

    Google Scholar 

  10. Cudkowicz G (1969) Hybrid resistance and parental specific transplantation antigens. In: Rose MR, Milgrom F (eds) Proceedings International Convocation on Immunology. Karger, Basel, p 193

    Google Scholar 

  11. Cudkowicz G (1975) Genetic control of resistance to allogeneic and xenogeneic bone marrow grafts in mice. Transplant Proc 7:155

    Google Scholar 

  12. Cudkowicz G, Hocham PS (1979) Do natural killer cells engage in regulated reactions against self to ensure homoestasis? Immunol Rev 44:13

    Google Scholar 

  13. Cudkowicz G, Rossi GB, Haddad JR, Friend C (1972) Hybrid resistance to parental DBA/2 grafts: independence from the H-2 locus. II. Studies in Friend virus-induced leukemia cells. J Natl Cancer Inst 48:997

    Google Scholar 

  14. Friend C (1957) Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med 105:307

    Google Scholar 

  15. Garaci E, Migliorati G, Jezzi T, Bartocci A, Gioia L, Rinaldi C, Bonmassar E (1981) Impairment of in vitro generation of cytotoxic or T suppressor lymphocytes by Friend leukemia virus infection in mice. Int J Cancer 28:367

    Google Scholar 

  16. Gorelik E, Wiltrout R, Okumura K, Habu S, Herberman RB (1982) Acceleration of metastatic growth in anti-Asialo GM1-treated mice. In: Herberman RB (ed) NK cells and other natural effector cells. Academic Press, New York, p 1331

    Google Scholar 

  17. Habu S, Fukui H, Shimamura K, Kasai M, Nagai Y, Okumura K, Tamaoki N (1981) In vivo effects of anti-Asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice. J Immunol 127:24

    Google Scholar 

  18. Haller O, Orn A, Gidlund M, Wigzell H (1980) In vitro activity of murine NK cells In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, p 1105

    Google Scholar 

  19. Hanna N (1982) Inhibition of experimental tumor metastasis by selective activation of natural killer cells. Cancer Res 42:1337

    Google Scholar 

  20. Harmon RC, Clark EA, Toole CO, Wicker LS (1977) Resistance of H-2 heterozygous mice to parental tumors. I. Hybrid resistance and natural cytotoxicity to EL-4 are controlled by the H-2D-Hh-1 region. Immunogenetics 4:601

    Google Scholar 

  21. Harrison DE, Carlson GA (1983) Effects of the beige mutation and irradiation on natural resistance to marrow grafts. J Immunol 130:484

    Google Scholar 

  22. Herberman RB (1982) Natural killer cells and their possible relevance to transplantation biology. Transplantation 34:1

    Google Scholar 

  23. Hochman PS, Cudkowicz G (1979) Suppression of natural cytotoxicity by spleen cells of hydrocortisone-treated mice. J Immunol 123:968

    Google Scholar 

  24. Hofer KG, Hughes L (1970) Incorporation of iododeoxy-uridine 125I into the DNA of L1210 leukemia cells during tumor development. Cancer Res 30:236

    Google Scholar 

  25. Houchens D, Iorio A, Barzi A, Goldin A, Bonmassar E (1975) Inhibition of anti-lymphoma allograft response in normal and lethally irradiated mice by cyclophosphamide (NCS 26271) and isophosphamide (NCS 109724). Cancer Chemother Rep 59:967

    Google Scholar 

  26. Iorio A, Campanile F, Neri M, Spreafico F, Goldin A, Bonmassar E (1978) Inhibition of lymphoma growth in the spleen and liver of lethally irradiated mice. J Immunol 120:1679

    Google Scholar 

  27. Iorio A, Neri M, Enrico P, Bonmassar E (1981) Inhibition of hybrid resistance to lymphomas by inactivated tumor cells in lethally irradiated mice. Transplantation 32:355

    Google Scholar 

  28. Kasai M, Leclerc JC, McVay-Boudreau L, Shen FW, Cantor H (1979) Direct evidence that natural killer cells in non-immune spleen cell population prevent tumor growth in vivo. J Exp Med 149:1260

    Google Scholar 

  29. Kiessling R, Hochman PS, Haller O, Shearer GM, Wigzell H, Cudkowicz G (1977) Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts. Eur J Immunol 7:655

    Google Scholar 

  30. Kumar V, Luevano E, Bennett M (1978) Hybrid resistance to EL-4 lymphoma cells. I. Characterization of natural killer cells that lyse EL-4 cells and their distinction from marrow dependent natural killer cells. J Exp med 150:531

    Google Scholar 

  31. Lotzovà E (1980) Analogy between rejection of hemopoietic transplants and natural killing. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, p 1117

    Google Scholar 

  32. Lotzovà E, Pollack SB, Savary CA (1982) Direct evidence for the involvement of natural killer cells in bone marrow transplantation. In: Herberman RB (ed) NK cells and other natural effector cells. Academic Press, New York, p 1535

    Google Scholar 

  33. Migliorti G, Jezzi T, Favalli G, Garaci E, Rossi GB, Bonmassar E (1982) Impairment of splenic natural killer cell activity in mice infected with the polycythemic strain of Friend leukemia virus. Cancer Immunol Immunother 12:177

    Google Scholar 

  34. Migliorati G, Jezzi T, Frati L, Bonmassar E, Rossi GB, Garaci E, Riccardi C (1983) Modulation of natural killer (NK) cell activity during FLV-P virus infection of mice. Int J Cancer 31:81

    Google Scholar 

  35. Mirand EA, Steevens RA, Lange RD, Grace JT (1968) Virus-induced polycythemia in mice: erythropoiesis without erythropoietin. Proc Soc Exp Biol Med 128:844

    Google Scholar 

  36. Mortensen RF, Ceglowski WS, Friedman H (1973) Leukemia virus-induced immunosuppression. IX. Depression of delayed hypersensitivity and MIF production after infection of mice with Friend leukemia virus. J Immunol 111:1810

    Google Scholar 

  37. Okumura K, Habu S, Shimamura K (1982) The role of Asialo GM1+ (GA1+) cells in the resistance to transplants of bone marrow or other tissues. In: Herberman RB (ed) NK cells and other natural effector cells. Academic Press, New York, p 1527

    Google Scholar 

  38. Plata F, Goodenow MM, Lilly F (1980) Studies of cloned Friend erythroleukemia tumor cells. Modulation of the tumor-specific cytolytic T lymphocyte response by infectious Friend virus production in vitro. J Exp Med 151:726

    Google Scholar 

  39. Pollack SB, Hallenbeck LA (1982) In vivo reduction of NK activity with anti-NK1 serum: direct evaluation of NK cells in tumor clearance. Int J Cancer 29:203

    Google Scholar 

  40. Riccardi C, Santoni A, Barlozzari T (1979) Immunomodulation of natural reactivities against tumors. Chemioter Oncologica 4:299

    Google Scholar 

  41. Riccardi C, Santoni A, Barlozzari T, Herberman RB (1980) Role of NK cells in rapid in vivo clearance of radiolabeled tumor cells. In: Herberma RB (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, p 1121

    Google Scholar 

  42. Riccardi C, Santoni A, Barlozzari T, Puccetti P, Herberman RB (1980) In vivo natural reactivity of mice against tumor cells. Int J Cancer 25:475

    Google Scholar 

  43. Roder JC, Haliotis T (1980) Do NK cells play a role in antitumor surveillance? Immunology Today 1:96

    Google Scholar 

  44. Rossi GB, Cudkowicz G, Friend C (1970) Evidence for transformation of spleen cells one day after infection of mice with Friend leukemia virus. Autonomous growth potential and expression of hybrid-resistance genes. J Exp Med 131:765

    Google Scholar 

  45. Rowson KE, Mahy BWJ (1975) Lactic dehidrogenase virus. Virol Monogr 13:1

    Google Scholar 

  46. Talmadge JE, Meyers KM, Prieur DJ, Starkey JR (1980) Role of NK cells in tumor growth and metastasis in beige mice. Nature 284:622

    Google Scholar 

  47. Thorn RM, Henney CS (1976) Kinetic analysis of target cell destruction by effector T cells. I. Delineation of parameters related to the frequency and lytic efficiency of killer cells. J Immunol 117:2213

    Google Scholar 

  48. Warner JF, Dennert (1982) Effects of a cloned cell line with NK activity on bone marrow transplants, tumor development and metastasis in vivo. Nature 300:31

    Google Scholar 

  49. Warner NL, Woodruff MF, Burton RC (1977) Inhibition of the growth of lymphoid tumours in syngeneic athimic (nude) mice. Int J Cancer 20:146

    Google Scholar 

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Authors and Affiliations

  1. Department of Virology, Institute of Hygiene, University of Perugia, Perugia, Italy

    A. M. Iorio, M. Neri & P. Enrico

  2. Departments of Virology, Istituto Superiore di Sanita', and of Cellular and Developmental Biology, Faculty of Biological Sciences, University of Rome, Rome, Italy

    F. Titti & G. B. Rossi

  3. Department of Experimental Medicine and Biochemical Sciences, 2nd University of Rome, Rome, Italy

    E. Bonmassar

Authors
  1. A. M. Iorio
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  2. M. Neri
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  3. P. Enrico
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  4. F. Titti
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  5. G. B. Rossi
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  6. E. Bonmassar
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Additional information

Abbreviations used: FLV-P, N-tropic polycythemic substrain of Friend Leukemia Virus Complex; NR, natural resistance; NR in vivo, natural resistance against normal or malignant hemopoietic grafts occurring in vivo in lethally irradiated mice; NK, natural killer; (125I)IUdR, 125I-labeled 5-iodio-2′-deoxyuridine; IV, intravenous

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Iorio, A.M., Neri, M., Enrico, P. et al. Natural resistance against hematopoietic cells in lethally-irradiated mice infected with Friend leukemia virus. Cancer Immunol Immunother 18, 35–40 (1984). https://doi.org/10.1007/BF00205397

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  • DOI: https://doi.org/10.1007/BF00205397

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