Summary
In this study biopsy specimens of the surface repair tissue from the weightbearing area of the hip joint were collected from 15 patients who had undergone successful valgus osteotomy, and these were examined histologically. In 6 of the 15 patients the specimens stained strongly with safranin-O in all three layers of the matrix. However, the repair tissue from another 6 patients showed strong staining only in the intermediate and deep layers, while that from 2 patients stained only in the deep layer. Specimens from 5 patients were stained for S-100 protein and positive cells were detected in all cases, demonstrating that the cells in the repair tissue were chondrocytes. However, there was no tide mark in the repair tissue and the arrangement of the cells differed from that in normal cartilage. Discontinuity of the subchondral bone was also noted. These findings make it likely that the repair tissue was of bone marrow origin.
Résumé
On a effectué l'examen histologique de 15 échantillons biopsiques du tissu de régénération cartilagineux de la surface d'appui de l'articulation de la hanche. Ces échantillons ont été prélevés sur 15 malades qui avaient subi avec succès une ostéotomie de valgisation fémorale. Chez 6 des ces 15 patients, les 3 couches du tissu de régénération étaient fortement colorées par la safranine O. Cependant, chez 6 autres patients, cette coloration n'était observée que dans les couches intermédiaires et profondes, tandis que, chez 2 patients, seule la couche profonde était colorée. Une immuno-histochimie pratiquée avec la protéine S-100 sur 5 échantillons a permis le marquage de toutes les cellules. Ceci a montré que les cellules du tissu de régénération étaient des chondrocytes. Cependant il n'y avait pas de ligne d'ossification dans le tissu de régénération et l'agencement des cellules différait de celui d'un cartilage normal. On a noté également une discontinuité de l'os sous-chondral. Ces résultats indiquent qu'il est trés probable que le tissu de régénération soit d'origine médullaire.
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Supported by grant from the Hip Joint Foundation of Japan. Part of this article was read at the SICOT meeting, Montreal, Canada, September 11, 1990
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Itoman, M., Yamamoto, M., Yonemoto, K. et al. Histological examination of surface repair tissue after successful osteotomy for osteoarthritis of the hip joint. International Orthopaedics 16, 118–121 (1992). https://doi.org/10.1007/BF00180199
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DOI: https://doi.org/10.1007/BF00180199