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Der Durchsatz der Bence-Jones-Proteine

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Zusammenfassung

Ein Bence-Jones-Protein wurde aus dem Urin von zwei Plasmozytomträgern isoliert, mit131J markiert und bei denselben Versuchspersonen, bei anderen Plasmozytomträgern, bei einem Nephrosklerotiker und bei zwei gesunden Versuchspersonen intravenös injiziert.

In allen untersuchten Fällen wurde das abnorme Protein teils mit dem Urin ausgeschieden, teils im Organismus abgebaut. Die höchste Abbaugeschwindigkeit wurde bei den gesunden Versuchspersonen gefunden. Es ergab sich, daß das Verhältnis zwischen Ausscheidungs- und Abbauquote bei den Patienten mit reichlicher Bence-Jones-Proteinurie höher war.

Es wird außerdem angenommen, daß eine gewisse Menge des Bence-Jones-Proteins den Kreislauf verläßt und von den Geweben des Organismus aufgehalten wird.

Summary

A Bence-Jones protein was isolated from the urine of two persons with a plasmocytoma. This protein was labelled with131J, and, by intravenous injection, administered to the same test persons, to other persons with a plasmocytoma, to a person with nephrosclerosis, and to two healthy test persons.

In all cases studied, the abnormal protein was partly excerted with the urine, partly metabolized inside the organism. The highest metabolic rate was found in healthy test persons. It was shown that the ratio between the excretion quota and metabolization quota was increased in patients with abundant Bence-Jones proteinuria.

Furthermore, it is assumed that a certain amount of Bence-Jones protein escapes from the circulation and is retained by the organism's tissues.

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Author notes

  1. U. Salera

    Present address: „Istituto di Clinica Medica” der Universität Rom, Roma

Authors and Affiliations

  1. „Istituto di Clinica Medica” der Universität Rom, Roma

    P. Magnanelli, N. A. Serafini, G. di Tomassi & S. Sanguigni

Authors
  1. U. Salera
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  2. P. Magnanelli
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  3. N. A. Serafini
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  4. G. di Tomassi
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  5. S. Sanguigni
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Salera, U., Magnanelli, P., Serafini, N.A. et al. Der Durchsatz der Bence-Jones-Proteine. Blut 13, 81–85 (1966). https://doi.org/10.1007/BF01632008

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  • DOI: https://doi.org/10.1007/BF01632008

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