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Der Intrinsic Factor

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Zusammenfassung

Der im Magen gebildete Intrinsic Factor ist für die unter physiologischen Bedingungen im weiteren Ileum erfolgende Resorption des mit der Nahrung aufgenommenen Vitamin B12 essentiell. Er gehört zur Gruppe der Glykoproteine. Die elektronegativen Kohlenhydratgruppen — hier speziell die Azylneuraminsäuren — schützen die für die biologische Wirkung spezifischen Proteinstrukturen gegen den Angriff tryptischer Enzyme im Verdauungstrakt. Das Glykoprotein kann bei Degeneration der Magen-Mukosa-Zellen in die Blutstrombahn gelangen und somit die Bildung zirkulierender Antikörper gegen Intrinsic Factor und Mukosa-Zellen auslösen. Dies mag für die Pathogenese der durch Intrinsic-Factor-Mangel verursachten perniziösen Anämie von entscheidender Bedeutung sein.

Summary

The Intrinsic Factor which is formed in the stomach is essential for the absorption of vitamin B12 taken with the food which takes place under physiological conditions in the ileum. It belongs to the group of glycoproteins. The electronegative carbohydrate group-here particularly the acylneuramic acids-protect the protein structures which are specific for the biological effect against the attack of tryptic enzymes in the gastrointestinal tract. If cells of the gastric mucosa degenerate, the glycoprotein may enter the circulation and thus is may trigger the formation of circulating antibodies to the Intrinsic Factor and to cells from the mucosa. This may be of decisive importance for the pathogenesis of pernicious anemia which is due to an Intrinsic Factor deficiency.

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Author notes

  1. H. Faillard

    Present address: Institut für phyiologische Chemie der Ruhr-Universität Bochum, Postfach 2148, 463, Bochum

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    Faillard, H. Der Intrinsic Factor. Blut 19, 238–245 (1969). https://doi.org/10.1007/BF01641720

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