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Anti-K2 (Cellano) blood group antibodies

Typing as IgG and IgA with a review of their clinical significance

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Summary

The data of the 16 cases of anti-K2 (Cellano) antibodies, reported in the literature, were compiled and discussed in greater detail. They are in agreement with the assumption of an immune nature of this rare but clinically important antibody. Two incomplete anti-K2 antibodies, originating from a patient with a transfusion accident, and from an immunized donor, -by means of DEAE cellulose chromatography—were found not only in the IgG but also in the IgA class. An anti-C antibody in one of these cases (same titre value 1∶512) was found only as IgG. The different properties of this antibody lead to the assumption that the occurence of an antibody as IgA besides the main parts as IgG resp. IgM, may indicate an immune response of special strength, due to repeated antigenic stimuli and/or duration of immunization.

Zusammenfassung

Die Daten der 16 in der Literatur veröffentlichten Fälle von Anti-K2 (Cellano)-Antikörpern wurden tabellarisch erfaßt und diskutiert. Sie stehen in Übereinstimmung mit der Annahme einer Immun-Natur dieses seltenen, aber klinisch wichtigen Antikörpers. 2 inkomplette Anti-K2-Antikörper, die von einem Patienten mit Transfusionszwischenfall und von einem immunisierten Spender stammten, verteilten sich nach DEAE-Zellulose-Chromatographie nicht nur auf die IgG-, sondern auch auf die IgA-Klasse. Ein sekundärer Anti-C-Antikörper in einem dieser Fälle mit gleicher Titerhöhe (1∶512) fand sich nur als IgG. Die verschiedenen Eigenschaften dieses sekundären Antikörpers führten zu der Annahme, daß das Vorkommen eines Antikörpers als IgA neben dem Hauptanteil als IgG bzw. IgM eine verstärkte Immunantwort infolge wiederholter Antigenstimuli und/oder längerer Immunisierungsdauer anzeigt.

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References

  1. Abelson, Neva M. and A. J. Rawson: Bibl. haemat. (Basel-New York)19, 491 (1964).

    Google Scholar 

  2. Adinolfi, M., P. L. Mollison, Margret Polley and Jane M. Rose. J. exp. Med.123, 951 (1966).

    Google Scholar 

  3. Allen, F. H. and R. E. Rosenfield: Transfusion (Philadelphia)1, 305 (1961).

    Google Scholar 

  4. Angevine, C. D., B. R. Andersen and E. V. Barnett: J. Immunol.96, 578 (1966).

    Google Scholar 

  5. Bryant, L. R.: Bull. Sth. Central Ass. Blood Banks8, 4 (1965).

    Google Scholar 

  6. Chattoraj, A., R. Gilbert and A. M. Josephson: Amer. J. clin. Path.49, 652 (1967).

    Google Scholar 

  7. Crabbé, P. A., D. R. Nash, H. Bazin, H. Eyssen and J. F. Heremans: J. exp. Med.130, 723 (1969).

    Google Scholar 

  8. Crawford, H.: J. clin. Path.6, 52 (1953).

    Google Scholar 

  9. Deutsch, H. F. and Jane J. Morton: Science (Washington)125, 600 (1957).

    Google Scholar 

  10. Dodd, Barbara E. and P. C. Wilkinson: J. exp. Med.120, 45 (1964).

    Google Scholar 

  11. Dunsford, I., M. Barber, M. C. Huth and T. E. Wilson: Vox Sang.4, 148 (1959).

    Google Scholar 

  12. Franklin, E. C.: Nature (London)195, 393 (1962).

    Google Scholar 

  13. Fudenberg, H. H., H. G. Kunkel and E. C. Franklin: Bibl. haemat. (Basel-New York)10, 522 (1959).

    Google Scholar 

  14. van der Giessen, M., Mia van der Hart and Ch. M. van der Weerdt: Vox Sang.9, 25 (1964).

    Google Scholar 

  15. Greenwalt, T. J., T. T. Sasaki and E. A. Steane: Transfusion (Philadelphia)7, 189 (1967).

    Google Scholar 

  16. Griffitts, J. J. and H. Drescher: Personal commun. (1968).

  17. Heistö, H., Else Vogt and Anna M. Heier in: Andresen P.H.: Papers in dedication of his 60th birthday. p. 80, Munksgaard, Copenhagen 1957.

    Google Scholar 

  18. Högman, C. F. and J. Killander: Bibl. haemat. (Basel-New York)19, 556 (1964).

    Google Scholar 

  19. Hopkins, D. F.: Brit. J. Haemat.17, 597 (1969).

    Google Scholar 

  20. Inella, Filomena P., C. R. Boyd and G. B. Stansell: Blood11, 641 (1956).

    Google Scholar 

  21. Ishizaka, K., T. Ishizaka and Evelyn H. Lee: J. Immunol.95, 771 (1965).

    Google Scholar 

  22. Ishizaka, K., T. Ishizaka, Evelyn H. Lee and H. H. Fudenberg: J. Immunol.95, 197 (1965).

    Google Scholar 

  23. Jungfer, H.: Med. Diss. Univ. Heidelberg 1968.

  24. Jungfer, H.: Z. Immunforsch.139, 182 (1970).

    Google Scholar 

  25. Keller, Dorothee H. and Patricia A. Peterman: Amer. J. med. Technol.31, 346 (1965).

    Google Scholar 

  26. Kissmeyer-Nielsen, F.: Monatskurse ärztl. Fortbild.16, 78 (1966).

    Google Scholar 

  27. Kissmeyer-Nielsen, F.: Personal commun. (1969).

  28. Kluge, A., E. Krah and H. E. Franz: Blut18, 267 (1969).

    Google Scholar 

  29. Kluge, A., E. Krah and Kl. Schimpf: Thrombos. diathes. haemorrh. (Stuttgart)21, 472 (1969).

    Google Scholar 

  30. Kunkel, H. G. and J. H. Rockey: Proc. Soc. exp. Biol. Med.113, 278 (1963).

    Google Scholar 

  31. Lang, B. G. and T. W. Lodge: Vox Sang.6, 353 (1961).

    Google Scholar 

  32. Levi, H. B. and H. A. Sober: Proc. Soc. exp. Biol. Med.103, 250 (1960).

    Google Scholar 

  33. Levine, Ph., May Backer, M. Wigod and Ruth Ponder: Science (Washington)109, 464 (1949).

    Google Scholar 

  34. Levine, Ph., A. B. Kuhmichel and M. Wigod: Blood7, 251 (1952).

    Google Scholar 

  35. Levine, Ph., Elizabeth A. Koch, R. T. McGee and G. H. Hill: Amer. J. clin. Path.24, 292 (1954).

    Google Scholar 

  36. Levine, Ph.: Personal commun. (1967).

  37. Levine, Ph., M. Wigod, Abby M. Backer and Ruth Ponder: Blood4, 869 (1949).

    Google Scholar 

  38. Lewis, Marion, B. Chown and R. F. Peterson: Amer. J. phys. Anthrop.13, 323 (1955) cit. after [44].

    Google Scholar 

  39. Mancini, G., A. O. Carbonara and J. F. Heremans: Immunochemistry2, 235 (1965).

    Google Scholar 

  40. Mollison, P. L., M. C. Adinolfi and Margret J. Polley: Bibl. haemat. (Basel-New York)19, 558 (1964).

    Google Scholar 

  41. Newstead, P. H. and Nona Bruce: Canad. J. med. Technol. (Hamilton, Ontario)23, 127 (1961).

    Google Scholar 

  42. Pettenkofer, H. J. and H. H. Hennemann: Blut3, 149 (1957).

    Google Scholar 

  43. Pike, R. M. and Mary L. Schulze: Immunology (London)4, 425 (1961).

    Google Scholar 

  44. Race, R. R. and Ruth Sanger: Die Blutgruppen des Menschen. (Thieme, Stuttgart 1958) p. 187.

    Google Scholar 

  45. Roelcke, D. and H. Jungfer: Clin. chim. Acta27, 211 (1970a).

    Google Scholar 

  46. Roelcke, D. and H. Jungfer: Klin. Wschr.48, 752 (1970b).

    Google Scholar 

  47. Roelcke, D. and W. Dorow: Klin. Wschr.46, 126 (1968).

    Google Scholar 

  48. Roelcke, D., G. Uhlenbruck and K. Bauer: Scand. J. haemat.6, 280 (1969).

    Google Scholar 

  49. Shapiro, M.: South Afr. med. J.26, 951 (1952).

    Google Scholar 

  50. Schmidt, P. J., Mary McGinniss, W. C. Leyshon and S. Kevy: Vox Sang.3, 438 (1958).

    Google Scholar 

  51. Thomas, Martha J. and Angelyn A. Konugres: Vox Sang.11, 227 (1966).

    Google Scholar 

Download references

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Author notes

  1. A. Kluge

    Present address: Blutbank-Serologie, Postfach 1503, D-6900, Heidelberg

Authors and Affiliations

  1. Blood Transfusion Center, Institute for Immunology and Serology, University of Heidelberg, Heidelberg, Germany

    A. Kluge & H. Jungfer

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  1. A. Kluge
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  2. H. Jungfer
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Kluge, A., Jungfer, H. Anti-K2 (Cellano) blood group antibodies. Blut 21, 357–365 (1970). https://doi.org/10.1007/BF01632165

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