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Iron deficiency anaemia and ‘normal’ bone marrow haemosiderin

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Summary

During a survey of patients with epithelial symptoms, pica and restless legs an apparently normal amount of stainable iron was found in the bone marrow of four women with chronic iron deficiency anaemia. They all had previously been treated with different parenteral iron preparations. No massive iron dextran infusion had been given. The diagnosis of iron deficiency was confirmed by a positive response to iron therapy. There was no indication that these iron complexes which were slowly utilized (if at all) had any harmful effects. The finding is primarily important from a diagnostic point of view.

Zusammenfassung

Bei der Durchsicht eines Patientenmaterials mit epithelialen Symptomen, Phagomania compulsiva (“pica”) und “restless legs” fand man bei vier weiblichen Patienten mit chronischer Eisenmangelanämie offenbar normale Mengen anfärbbaren Eisens im Knochenmark. Sie waren früher alle mit verschiedenen parenteralen Eisenpräparaten behandelt worden. Es waren keine größeren Mengen Eisen-Dextran infundiert worden. Die Diagnose Eisenmangel wurde durch die positive Reaktion auf Behandlung mit Eisen bestätigt. Es ergab sich kein Anhalt dafür, daß diese Eisenkomplexe, die langsam (wenn überhaupt) verwertet werden, irgendwelche schädlichen Wirkungen zeigen. Der Befund hat in erster Linie diagnostische Bedeutung.

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Jameson, S., Killander, A. & Wadman, B. Iron deficiency anaemia and ‘normal’ bone marrow haemosiderin. Blut 23, 61–68 (1971). https://doi.org/10.1007/BF01632733

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  • DOI: https://doi.org/10.1007/BF01632733

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