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Biological and clinical relevance of human macrophage migration inhibitory factor (MIF)

Biologische und klinische Bedeutung des menschlichen Hemmfaktors der Makrophagenmigration (MIF)

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Zusammenfassung

Die erste Isolierung und Charakterisierung eines Lymphokins, des menschlichen MIF (MSF), und die Gewinnung eines spezifischen MIF (MSF)-Antikörpers eröffnen die Möglichkeit, neue Parameter für die Bestimmung zellulärer Immunmechanismen bei verschiedenen klinischen Situationen zu gewinnen. Die genaue quantitative Bestimmung mit empfindlichen immunochemischen Techniken könnte einen Einblick in die Pathogenese verschiedener klinischer Erkrankungen ermöglichen. Zusätzlich könnte der quantitativen Bestimmung von MIF in Körperflüssigkeiten eine prognostische Bedeutung zukommen.

Summary

The first isolation and characterization of a lymphokine, the human MIF (MSF), and the availability of a specific MIF (MSF)-antibody provide an opportunity to establish a new parameter for detection of cellular immune mechanisms in various clinical situations. The precise estimation of quantitative amounts of MIF by sensitive immunochemical techniques could gain new insights into the pathogenesis of a number of clinical disorders. In addition, the exact detection of quantitative amounts of MIF in body fluids could have prognostic value.

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Authors and Affiliations

  1. School of Medicine, Infectious Disease Section, Department of Internal Medicine, Yale University, 06510, New Haven, CT, USA

    L. H. Block

  2. Max-Planck-Institut für Biochemie, D-8033, Martinsried bei München, Germany

    G. Ruhenstroth-Bauer

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  1. L. H. Block
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Block, L.H., Ruhenstroth-Bauer, G. Biological and clinical relevance of human macrophage migration inhibitory factor (MIF). Blut 38, 93–101 (1979). https://doi.org/10.1007/BF01007950

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