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Crossreaction of monoclonal Anti-T-cell antibodies: Implications for classifying B-cell leukemias

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Summary

Cell samples from 62 patients with B-cell leukemias (33 CLL, 8 IC, 6 PLL, 4 HCL, 2 ALL and 9 other NHL) were tested with a series of monoclonal antibodies (A50, T101, Lyt2, Leu1, M203) directed against T cells and shown to crossreact with B-CLL. The results demonstrate a heterogeneity of B-cell leukemias as all typical cases of CLL were reactive whereas most other cases were negative. Using the fluorescence-activated cell sorter, a somewhat stronger reaction was seen in early or benign cases of CLL, compared to advanced cases. All B-cell leukemias tested expressed the Ia antigen.

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Authors and Affiliations

  1. Abteilung Immunologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Institut für Hämatologie, Landwehrstraße 61, D-8000, München 2, Federal Republic of Germany

    R. Munker, E. Thiel, U. Kummer, H. Rodt & S. Thierfelder

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  1. R. Munker
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  2. E. Thiel
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  3. U. Kummer
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  4. H. Rodt
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  5. S. Thierfelder
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Munker, R., Thiel, E., Kummer, U. et al. Crossreaction of monoclonal Anti-T-cell antibodies: Implications for classifying B-cell leukemias. Blut 46, 95–100 (1983). https://doi.org/10.1007/BF00320665

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  • DOI: https://doi.org/10.1007/BF00320665

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