Summary
A 19-year old girl with severe cyclical neutropenia associated with life-threatening infection and who responded dramatically to the administration of oral prednisolone is described. During reduction and eventual cessation of steroid therapy normal or near normal neutrophil counts have been maintained, and there has been parallel improvement in clinical well-being. Prior to therapy and at a time of peak blood neutrophil count low numbers of granulocyte-macrophage progenitor cells (CFU-C) were found in the patient's bone marrow, and her lymphocytes co-cultured with normal marrow failed to show the inhibitory effect normally seen with normal lymphocytes.
The findings in this patient are compared with those in the two other cases where cyclical neutropenia has been shown to respond to steroids.
Similar content being viewed by others
References
Barkve H (1967) Cyclic neutropenia: Report of a case treated with high dose testosterone. Acta Med Scand 182: 503
Baxter HD (1976) Glucocorticoid hormone action. Pharmacol Ther (B) 2: 605
Böyum A (1976) Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol 5: 9
Brodsky I, Reimann HA, Dennis LH (1965) Treatment of cyclic neutropenia with testosterone. Am J Med 38: 802
Claas FHJ, Langerak J, Sabbe LJM, Rood JJ van (1979) NEI: A new neutrophilic-specific antigen. Tissue Antigens 13: 129
Coventry WD (1953) Cyclic neutropenia: Report of a case treated by splenectomy. J Am Med Assoc 153: 28
Good RA, Varco RL (1955) Clinical and experimental study of agammaglobulinaemia. Lancet 75: 245
Lange RD, Jones JB (1982) Cyclic hematopoiesis: Etiological concepts. Clinical research update. Am J Pediatr Hematol Oncol 4: 223
Magnin GE, Suits JJ, Wenzel F (1957) Cyclic neutropenia: Report of a case treated with splenectomy. Wisconsin Med J 56: 192
Morris TCM, Vincent PC, Young GAR, Sutherland R, Forrest PR, Isbister JP CFU-C inhibitors in aplastic anaemia. Submitted for publication
Page AR, Good RA (1957) Studies on cyclic neutropenia. Am J Dis Child 94: 623
Robinson WA, Pike B (1970) Colony growth of human bone marrow cells in vitro. In: Stohlman F Jr (ed) Hemopoietic cellular proliferation. Grune and Stratton, New York, p 249
Rodgers GM, Shuman MA (1982) Acquired cyclic neutropenia: Successful treatment with prednisone. Am J Hematol 13: 83
Roozendaal HK, Dicke KA, Boonzajer Flaes ML (1981) Effect of oxymetholone on human cyclic haematologiesis. Br J Hematol 47: 185
Saxon D, Stevens RH, Ramer SJ, Clements PJ, Yu DTY (1978) Glucocorticoids administered in vivo inhibit human suppressor T lymphocyte function and diminish B lymphocyte responsiveness in in vitro immunoglobulin synthesis. J Clin Invest 61: 922
Wright DG, Dale DC, Fauci AS, Wolff SM (1981) Human cyclic neutropenia: Clinical review and long-term follow-up of patients. Medicine 60: 1
Wright DG, Fauci AS, Dale DC, Wolff SM (1978) Correction of human cyclic neutropenia with prednisolone. N Engl J Med 298: 295
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Young, G.A.R., Iland, H.J., Deveridge, S.F. et al. Steroid responsive cyclical neutropenia. Blut 48, 153–159 (1984). https://doi.org/10.1007/BF00320338
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320338