Summary
A patient with acute myelomonocytic leukemia who experienced a spontaneous remission, is reported. He had precedent and concurrent bacterial infections as most of these cases described. Low peripheral WBC and myeloblasts, Auer-rod positive blasts, bone marrow eosinophilia with atypical eosinophils, and a partial deletion of chromosome 16 were favorable prognostic parameters. A brief review of the literature and possible explanations for the regulation of granulopoiesis are presented.
Similar content being viewed by others
References
Eisenlohr C (1878) Leucaemia lienalis, lymphatic et medularis mit multiplen Gehirnnervenlähmungen. Virchow's Arch (Pathol Anat) 73: 56–73
Tivey H (1954) The natural history of untreated leukemia. Ann NY Acad Sci 60: 322–357
Lachant NA, Goldberg J, Nelson DA, Gottlieb AJ (1979) Spontaneous remission in acute myelogenous leukemia in the adult. Am J Med 67: 687–692
Diamond LK, Luhby AL (1951) Pattern of “spontaneous” remissions in leukemia of childhood observed in 26 of 300 cases. Am J Med 10: 238–239
Leblanc A, Allard C (1981) Remission spontanée de leucémie aiguë chez deux enfants. Arch Fr Pédiatr 38: 275–276
Ifrah N, James JM, Vigne F, Marie JP, Zittoun R (1985) Spontaneous remission in adult acute leukemia. Cancer 56: 1187.1130
Dock G (1902) The influence of complicating diseases upon leukaemia. Am J Med Sci 127: 563–593
Pelner L, Fowler GA, Nauts HC (1958) Effects of concurrent infections and their toxins on the course of leukemia. Acta Med Scand (Suppl) 338: 5–47
Nauts HC, Swift WE, Coley BL (1946) The treatment of malignant tumors by bacterial toxins as developed by the late Wilhelm B. Coley, MD, Reviewed in light of modern research. Cancer Research 6: 205–216
Taylor AW (1953) Effects of glandular fever infection in acute leukemia. Br Med J 1: 589–593
Passe S, Miké V, Mertelsmann R, Gee TS, Clarkson BD (1982) Acute nonlymphoblastic leukemia: Prognostic factors in adults with long-term follow-up. Cancer 50: 1462–1471
Wade IC, Wiernik PH, Schimpff SC, Schiffer CA (1980) Hepatitis prolongation of complete remission and survival in acute nonlymphocytic leukemia (ANLL) patients. ASCO Abstr C 474: p 43
Zittoun R, Cadiou M, Bayle C, Suciu S, Solbu G (1984) Hayat M, and the EORTC Leukemia and Hematosarcoma Group. Prognostic value of cytological parameters in acute myelogenous leukemia. Cancer 53: 1526–1532
Keating MJ (1982) Early identification of potentially cured patients with acute myelogenous leukemia — a recent challange. In: Bloomfield CD (ed) Adult Leukemia. I Boston: Martinus Nijhoff, 237–262
Le Beau MM, Larson RA, Bitter MA, Verdiman JW, Golomb HM, Rowley JD (1983) Association of inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. New Engl J Med 309: 630–633
Arhur DC, Bloomfield CD (1983) Correspondence. Blood 62: 931
Tantravalu R, Schwenn M, Henkle C, Nell M, Leavitt PR, Griffin JD, Weinstein H (1984) A pericentric inversion of chromosome 16 is associated with dysplastic marrow eosinophils in acute myelomonocytic leukemia. Blood 63: 800–802
Verma DS, Johnston DA, McCredie KB (1983) Evidence for the separate human T-lymphocyte subpopulations that collaborate with autologous monocyte/macrophages in the elaboration of colony-stimulating activity and those that suppress this collaboration. Blood 62: 1088–1099
Moore MAS, Gabrilove J, Hishant Y, Pinsky C, Oetgen H (1982) Induction of a myeloid leukemia differentiation factor (GM-DF) in human post endoxin sera (Abstr). Proc Am Cancer Res 23: 114
Barr RD, Stevens CA (1983) The role of autologous helper and suppressor T cells in the regulation of human granulopoiesis. Am J Hematol 12: 323–327
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jehn, U.W., Mempel, M.A. Spontaneous remission of acute myeloid leukemia. Blut 52, 165–168 (1986). https://doi.org/10.1007/BF00320532
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320532