Summary
We report the case of a 70-year-old woman suffering from small lymphocytic, plasmocytoid lymphoma with abdominal lymphomas and infiltration of the lung and the bone marrow. A three-banded, IgGλ, IgMλ and IgAλ-paraproteinemia was determined using immunofixation. Because of the patient's high antibody titre against cytomegalovirus (CMV), the possible reactivity of these paraproteins with CMV was studied. The immunoglobulins were transferred to nitrocellulose sheets by a contact diffusion blotting system. CMV was applied to these sheets and the IgGλ-paraprotein was shown to bind CMV. The reactivity of only one of the paraproteins with CMV suggests an oligoclonal origin of this gammopathy. In addition to the malignant disease an abnormal immune response to a CMV infection could be the cause of this three-banded gammopathy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- CMV:
-
cytomegalovirus
- BSA:
-
bovine serum albumine
- Ig:
-
immunoglobuline
- ELISA:
-
enzyme linked immuno sorbent assay
- CT:
-
computed tomography
References
Bussel A, Danon F, Ferchal F, Perol Y (1978) Cytomegalovirus infection in malignant blood diseases. Nouv Rev Fr Hematol 20: 67–76
Danon F, Seligmann M (1972) Transient human monoclonal immunoglobulins. Scand J Immunol 1: 323–328
Frizzera G, Hanto DW, Gajl-Peczalska J (1981) Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 41: 4262–4279
Fudenberg HH, Wang AC, Pink JRL, Levin AS (1971) Studies of an unusual biclonal gammopathy. Implications with regard to genetic control of normal immunoglobulin synthesis. Ann NY Acad Sci 190: 501–506
Gore ME, Riches PG, Kohn J (1979) Identification of the paraproteins and clinical significance of more than one paraprotein in serum of 56 patients. J Clin Pathol 32: 313–317
Hanto DW, Frizzera G, Purtilo DT (1981) Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res 41: 4253–4261
Hermes C, Daus H, Köhler M, Mauch H, Scheurlen PG (1985) Transitorische oligoklonale Paraproteinämie bei Virusinfektion und maligner lymphatischer Erkrankung. Dtsch Med Wochenschr 110: 837–840
Hopper JE (1977) Comparative studies on monotypic IgM and IgG from an individual patient. IV. Immunofluorescent evidence for a common clonal synthesis. Blood 50: 203–211
Krueger RG, Hilton PM, Boehlecke JM, Kyle RA, Fair DS (1980) The cellular origin of multiple monoclonal immunoglobulins reflects the postulated pathways of isotype differentiation of antibody-forming cells. Cell Immunol 54: 402–413
Kyle RA, Robinson RA, Katzmann JA (1981) The clinical aspects of bioclonal gammopathies. Review of 57 cases. Am J Med 71: 999–1008
Kyle RA (1982) Monoclonal gammopathy of undetermined significance (MGUS). A review. Clin Haematol 11: 123–150
Mattsson DM, Howard RJ, Balfour HH (1983) Immunosuppression-induced defective lymphocyte proliferation to murine cytomegalovirus is prolonged following the cessation of immunosuppression. Proc Soc Exp Biol Med 172: 51–59
Rádl J, Dooren LJ, Eijsvogel VP, van Went JJ, Hijmans W (1971) An immunological study during post-transplantation follow-up of a case of severe combined immunodeficiency. Clin Exp Immunol 10: 367–382
Rádl J, van den Berg P, Voormolen M, Hendriks WDH, Schaefer UW (1974) Homogenous immunoglobulins in sera of rhesus monkeys after lethal irradiation and bone marrow transplantation. Clin Exp Immunol 16: 259–266
Schroff RW, Gale RP, Fahey JL (1982) Regeneration of T-cell subpopulations after bone marrow transplantation: Cytomegalovirus infection and lymphoid subset imbalance. J Immunol 129: 1926–1930
Seigneurin JM, Renversez JC, Baccard M, Seigneurin D, Micouin C (1980) Monoclonal cryoimmunoglobulin with anti-cytomegalovirus activity associated with T-cell chronic lymphocytic leukaemia. Clin Exp Immunol 41: 317–325
Stoop JW, Zegers BJM, van der Heiden C, Ballieux RE (1968) Monoclonal gammopathy in a child with leukemia. Blood 32: 774–786
van Camp BGK, Shuit HRE, Hijmans W, Radl J (1978) The cellular basis of double paraproteinemia in man. Clin Immunol Immunopathol 9: 111–119
van Camp BGK, Raeneris P, Naets JP, Radl J (1980) Transient IgA-paraproteinemia during treatment of acute myelomonoblastic leukemia. Blood 55: 21–25
Vodopick H, Chaskes SJ, Solomon A, Stewart JA (1974) Transient monoclonal gammopathy associated with cytomegalovirus infection. Blood 44: 189–195
Waldenström JG (1982) The benign monoclonal gammopathies. A study of monoclonal antibodies. Ergeb Inn Med Kinderheilk 50: 31–77
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Köhler, M., Daus, H., Köhler, C. et al. Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: Reactivity of one of these paraproteins with cytomegalovirus. Blut 54, 25–32 (1987). https://doi.org/10.1007/BF00326023
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00326023