Summary
Screening of 143 children 6 months to 12 years of age with sickle-cell anemia showed that 39.2% were HBsAg-positive as compared with 19.3% of the 161 control children of the same age group, who had Hb genotype AA (χ2=14.7383; P<0.001). Fifty percent of the HbSS children under the age of 1 year were HBsAg-positive as opposed to 4.3% of the control group (χ2=9.1955; P<0.001), while 28.6% of patients were HBsAg-positive at the age of 4 years compared with only 7.4% of the controls at the same age. The incidence of anti-HBc in both groups was similar. Markers of HBV infection (HBsAg + anti-HBc) were, however, on the whole higher in the patients with sickle-cell anemia [88/118 (74.6%)] than in the controls [54/88 (61.3%; P<0.005)].
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Abiodun, P.O., Fatunde, O.J., Flach, K.H. et al. Increased incidence of hepatitis B markers in children with sickle-cell anemia. Blut 58, 147–150 (1989). https://doi.org/10.1007/BF00320435
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DOI: https://doi.org/10.1007/BF00320435