Summary
Leukocytopenia and bacterial infections are common and serious complications in patients with AIDS. We report here on three such patients in whom the administration of high IgG doses led to gradual (two patients) or prompt (one patient) increases in circulating leukocyte counts (from 200–600 to 2500–5900/μ1), inducing definite improvement in two patients; one patient died fromPneumocystis carinii pneumonia. Although the rise in leukocyte counts lasted for only approximately 3 weeks, high-dose IgG might be a useful therapeutic adjunct in such patients.
Similar content being viewed by others
References
Groopman JE, Mitsuyasu RT, de Leo MJ, Oette DH, Golde DW (1987) Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. N Engl J Med 317: 593–598
Murphy MF, Metcalfe P, Waters AH, Carne CA, Weller VD, Linch CD, Smith A (1987) Incidence and mechanism of neutropenia and thrombocytopenia in patients with human immunodeficiency virus infection. Br J Haematol 66: 337–340
Scadden DT, Zon LI, Groopman JE (1989) Pathophysiology and management of HIV-associated hematologic disorders. Blood 74: 1455–1463
Yap PL (1990) Intravenous immunoglobulin for secondary immunodeficiency. Blut 60: 8–14
Author information
Authors and Affiliations
Additional information
This work was supported by theDeutsche Forschungsgemeinschaft (Sa 405/1-3)
Rights and permissions
About this article
Cite this article
Salama, A., Lohmeyer, J., Seeger, W. et al. High-dose IgG for neutropenic patients with acquired immunodeficiency syndrome (AIDS). Ann Hematol 63, 77–78 (1991). https://doi.org/10.1007/BF01707276
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01707276